Neural correlates of working memory performance in primary insomnia

Sean Patrick Andrews Drummond, Matthew P Walker, Erin L Almklov, Manuel Campos, Dane E Anderson, Laura D Straus

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Study Objectives: To examine neural correlates of working memory performance in patients with primary insomnia (PIs) compared with wellmatched good sleepers (GSs). Design: Twenty-five PIs and 25 GSs underwent functional MRI while performing an N-back working memory task. Setting: VA hospital sleep laboratory and University-based functional imaging center. Patients or Participants: 25 PIs, 25 GSs. Interventions: N/A. Measurements and Results: Although PIs did not differ from GSs in cognitive performance, PIs showed the expected differences from GSs in both self-reported and objective sleep measures. PIs, relative to GSs, showed reduced activation of task-related working memory regions. This manifested both as an overall reduction in activation of task-related regions and specifically as reduced modulation of right dorsolateral prefrontal cortex with increasing task difficulty. Similarly, PIs showed reduced modulation (i.e., reduced deactivation) of default mode regions with increasing task difficulty, relative to GSs. However, PIs showed intact performance. Conclusions: These data establish a profile of abnormal neural function in primary insomnia, reflected both in reduced engagement of taskappropriate brain regions and an inability to modulate task-irrelevant (i.e., default mode) brain areas during working memory performance. These data have implications for better understanding the neuropathophysiology of the well established, yet little understood, discrepancy between ubiquitous subjective cognitive complaints in primary insomnia and the rarely found objective deficits during testing
Original languageEnglish
Pages (from-to)1307 - 1316
Number of pages10
JournalSleep
Volume36
Issue number9
DOIs
Publication statusPublished - 2013
Externally publishedYes

Cite this

Drummond, S. P. A., Walker, M. P., Almklov, E. L., Campos, M., Anderson, D. E., & Straus, L. D. (2013). Neural correlates of working memory performance in primary insomnia. Sleep, 36(9), 1307 - 1316. https://doi.org/10.5665/sleep.2952
Drummond, Sean Patrick Andrews ; Walker, Matthew P ; Almklov, Erin L ; Campos, Manuel ; Anderson, Dane E ; Straus, Laura D. / Neural correlates of working memory performance in primary insomnia. In: Sleep. 2013 ; Vol. 36, No. 9. pp. 1307 - 1316.
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abstract = "Study Objectives: To examine neural correlates of working memory performance in patients with primary insomnia (PIs) compared with wellmatched good sleepers (GSs). Design: Twenty-five PIs and 25 GSs underwent functional MRI while performing an N-back working memory task. Setting: VA hospital sleep laboratory and University-based functional imaging center. Patients or Participants: 25 PIs, 25 GSs. Interventions: N/A. Measurements and Results: Although PIs did not differ from GSs in cognitive performance, PIs showed the expected differences from GSs in both self-reported and objective sleep measures. PIs, relative to GSs, showed reduced activation of task-related working memory regions. This manifested both as an overall reduction in activation of task-related regions and specifically as reduced modulation of right dorsolateral prefrontal cortex with increasing task difficulty. Similarly, PIs showed reduced modulation (i.e., reduced deactivation) of default mode regions with increasing task difficulty, relative to GSs. However, PIs showed intact performance. Conclusions: These data establish a profile of abnormal neural function in primary insomnia, reflected both in reduced engagement of taskappropriate brain regions and an inability to modulate task-irrelevant (i.e., default mode) brain areas during working memory performance. These data have implications for better understanding the neuropathophysiology of the well established, yet little understood, discrepancy between ubiquitous subjective cognitive complaints in primary insomnia and the rarely found objective deficits during testing",
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Drummond, SPA, Walker, MP, Almklov, EL, Campos, M, Anderson, DE & Straus, LD 2013, 'Neural correlates of working memory performance in primary insomnia' Sleep, vol. 36, no. 9, pp. 1307 - 1316. https://doi.org/10.5665/sleep.2952

Neural correlates of working memory performance in primary insomnia. / Drummond, Sean Patrick Andrews; Walker, Matthew P; Almklov, Erin L; Campos, Manuel; Anderson, Dane E; Straus, Laura D.

In: Sleep, Vol. 36, No. 9, 2013, p. 1307 - 1316.

Research output: Contribution to journalArticleResearchpeer-review

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Drummond SPA, Walker MP, Almklov EL, Campos M, Anderson DE, Straus LD. Neural correlates of working memory performance in primary insomnia. Sleep. 2013;36(9):1307 - 1316. https://doi.org/10.5665/sleep.2952