NetB, a pore-forming toxin from necrotic enteritis strains of Clostridium perfringens

Anthony L Keyburn, Trudi L Bannam, Robert J Moore, Julian I Rood

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Abstract

The Clostridium perfringens necrotic enteritis B-like toxin (NetB) is a recently discovered member of the I?-barrel pore-forming toxin family and is produced by a subset of avian C. perfringens type A strains. NetB is cytotoxic for avian cells and is associated with avian necrotic enteritis. This review examines the current state of knowledge of NetB: its role in pathogenesis, its distribution and expression in C. perfringens and its vaccine potential.
Original languageEnglish
Pages (from-to)1913 - 1927
Number of pages15
JournalToxins
Volume2
Issue number7
DOIs
Publication statusPublished - 2010

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