Projects per year
Abstract
While strongly implicated in postural tachycardia syndrome (POTS), considerable controversy exists regarding norepinephrine transporter (NET) loss of function. POTS is characterized by the clinical symptoms of orthostatic intolerance, lightheadedness, tachycardia, and syncope or near syncope with upright posture. Abnormal sympathetic nervous system activity is typical, of a type which suggests dysfunction of the NET, with evidence that the gene responsible is under tight epigenetic control. Using RNA of isolated chromatin combined with massive parallel sequencing (RICh-seq) we show that let-7i miRNA suppresses NET by methyl-CpG-binding protein 2 (MeCP2). Vorinostat restores epigenetic control and NET expression in leukocytes derived from POTS participants.
Original language | English |
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Article number | e90183 |
Number of pages | 11 |
Journal | JCI Insight |
Volume | 2 |
Issue number | 6 |
DOIs | |
Publication status | Published - 23 Mar 2017 |
Projects
- 1 Finished
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Identifying the epigenomic fingerprint of coronary heart disease in Chinese adults with type 2 diabetes
El-Osta, S., Huang, Y., Chan, J. C. N., Thomas, M., Cooper, M. & Khurana, I.
1/01/16 → 31/12/20
Project: Research
Activities
- 1 Contribution to conference
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Stress, Behavior and the Heart
Sam El-Osta (Invited speaker)
5 Oct 2015Activity: Participating in or organising an event types › Contribution to conference