Neonatal brain abnormalities associated with autism spectrum disorder in children born very preterm

Alexandra M. Ure, Karli Treyvaud, Deanne K. Thompson, Leona Pascoe, Gehan Roberts, Katherine J. Lee, Marc L. Seal, Elisabeth Northam, Jeanie L. Cheong, Rod W. Hunt, Terrie Inder, Lex W. Doyle, Peter J. Anderson

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Very preterm (VP) survivors are at increased risk of autism spectrum disorder (ASD) compared with term-born children. This study explored whether neonatal magnetic resonance (MR) brain features differed in VP children with and without ASD at 7 years. One hundred and seventy-two VP children (<30 weeks' gestation or <1250 g birth weight) underwent structural brain MR scans at term equivalent age (TEA; 40 weeks' gestation ±2 weeks) and were assessed for ASD at 7 years of age. The presence and severity of white matter, cortical gray matter, deep nuclear gray matter, and cerebellar abnormalities were assessed, and total and regional brain volumes were measured. ASD was diagnosed using a standardized parent report diagnostic interview and confirmed via an independent assessment. Eight VP children (4.7%) were diagnosed with ASD. Children with ASD had more cystic lesions in the cortical white matter at TEA compared with those without ASD (odds ratio [OR] 8.7, 95% confidence interval [CI] 1.5, 51.3, P=0.02). There was also some evidence for smaller cerebellar volumes in children with ASD compared with those without ASD (OR=0.82, CI=0.66, 1.00, P=0.06). Overall, the results suggest that VP children with ASD have different brain structure in the neonatal period compared with those who do not have ASD.

Original languageEnglish
Pages (from-to)543-552
Number of pages10
JournalAutism Research
Volume9
Issue number5
DOIs
Publication statusPublished - May 2016
Externally publishedYes

Keywords

  • Autism spectrum disorder
  • Brain abnormality
  • Magnetic resonance imaging
  • Neonatal imaging
  • Preterm birth

Cite this

Ure, Alexandra M. ; Treyvaud, Karli ; Thompson, Deanne K. ; Pascoe, Leona ; Roberts, Gehan ; Lee, Katherine J. ; Seal, Marc L. ; Northam, Elisabeth ; Cheong, Jeanie L. ; Hunt, Rod W. ; Inder, Terrie ; Doyle, Lex W. ; Anderson, Peter J. / Neonatal brain abnormalities associated with autism spectrum disorder in children born very preterm. In: Autism Research. 2016 ; Vol. 9, No. 5. pp. 543-552.
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abstract = "Very preterm (VP) survivors are at increased risk of autism spectrum disorder (ASD) compared with term-born children. This study explored whether neonatal magnetic resonance (MR) brain features differed in VP children with and without ASD at 7 years. One hundred and seventy-two VP children (<30 weeks' gestation or <1250 g birth weight) underwent structural brain MR scans at term equivalent age (TEA; 40 weeks' gestation ±2 weeks) and were assessed for ASD at 7 years of age. The presence and severity of white matter, cortical gray matter, deep nuclear gray matter, and cerebellar abnormalities were assessed, and total and regional brain volumes were measured. ASD was diagnosed using a standardized parent report diagnostic interview and confirmed via an independent assessment. Eight VP children (4.7{\%}) were diagnosed with ASD. Children with ASD had more cystic lesions in the cortical white matter at TEA compared with those without ASD (odds ratio [OR] 8.7, 95{\%} confidence interval [CI] 1.5, 51.3, P=0.02). There was also some evidence for smaller cerebellar volumes in children with ASD compared with those without ASD (OR=0.82, CI=0.66, 1.00, P=0.06). Overall, the results suggest that VP children with ASD have different brain structure in the neonatal period compared with those who do not have ASD.",
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author = "Ure, {Alexandra M.} and Karli Treyvaud and Thompson, {Deanne K.} and Leona Pascoe and Gehan Roberts and Lee, {Katherine J.} and Seal, {Marc L.} and Elisabeth Northam and Cheong, {Jeanie L.} and Hunt, {Rod W.} and Terrie Inder and Doyle, {Lex W.} and Anderson, {Peter J.}",
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Ure, AM, Treyvaud, K, Thompson, DK, Pascoe, L, Roberts, G, Lee, KJ, Seal, ML, Northam, E, Cheong, JL, Hunt, RW, Inder, T, Doyle, LW & Anderson, PJ 2016, 'Neonatal brain abnormalities associated with autism spectrum disorder in children born very preterm' Autism Research, vol. 9, no. 5, pp. 543-552. https://doi.org/10.1002/aur.1558

Neonatal brain abnormalities associated with autism spectrum disorder in children born very preterm. / Ure, Alexandra M.; Treyvaud, Karli; Thompson, Deanne K.; Pascoe, Leona; Roberts, Gehan; Lee, Katherine J.; Seal, Marc L.; Northam, Elisabeth; Cheong, Jeanie L.; Hunt, Rod W.; Inder, Terrie; Doyle, Lex W.; Anderson, Peter J.

In: Autism Research, Vol. 9, No. 5, 05.2016, p. 543-552.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Ure, Alexandra M.

AU - Treyvaud, Karli

AU - Thompson, Deanne K.

AU - Pascoe, Leona

AU - Roberts, Gehan

AU - Lee, Katherine J.

AU - Seal, Marc L.

AU - Northam, Elisabeth

AU - Cheong, Jeanie L.

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AU - Anderson, Peter J.

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