Neocentromeres: New Insights into Centromere Structure, Disease Development, and Karyotype Evolution

Owen J. Marshall; Anderly C. Chueh; Lee H. Wong; K. H Andy Choo

doi:10.1016/j.ajhg.2007.11.009

Neocentromeres: New Insights into Centromere Structure, Disease Development, and Karyotype Evolution

Owen J. Marshall
, Anderly C. Chueh
, Lee H. Wong
, K. H Andy Choo

Research output: Contribution to journal › Review Article › Research › peer-review

315 Citations (Scopus)

Abstract

Since the discovery of the first human neocentromere in 1993, these spontaneous, ectopic centromeres have been shown to be an astonishing example of epigenetic change within the genome. Recent research has focused on the role of neocentromeres in evolution and speciation, as well as in disease development and the understanding of the organization and epigenetic maintenance of the centromere. Here, we review recent progress in these areas of research and the significant insights gained.

Original language	English
Pages (from-to)	261-282
Number of pages	22
Journal	American Journal of Human Genetics
Volume	82
Issue number	2
DOIs	https://doi.org/10.1016/j.ajhg.2007.11.009
Publication status	Published - 8 Feb 2008
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/j.ajhg.2007.11.009

Cite this

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Neocentromeres: New Insights into Centromere Structure, Disease Development, and Karyotype Evolution

Abstract

UN SDGs

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