Neoadjuvant Chemotherapy Alone for Early-Stage Rectal Cancer: An Evolving Paradigm?

Eliza A. Hawkes, David Cunningham, Diana Tait, Gina Brown, Ian Chau

Research output: Contribution to journalReview ArticleResearchpeer-review

2 Citations (Scopus)


Current management of early-stage rectal cancer comprises combinations of surgery, radiotherapy, and chemotherapy, with the presence or absence of several validated high-risk features determining which treatment modalities will be used and the order of administration. In high-risk individuals, most centers have adopted neoadjuvant combined chemotherapy and radiotherapy followed by surgery as the initial approach. However, long-term toxicity, limited survival gains, and high rates of distant failure have called this approach into question, with early data suggesting that neoadjuvant chemotherapy alone may be feasible in selected patient groups. This review discusses the current data and feasibility of managing early stage rectal cancer with neoadjuvant chemotherapy before surgical resection.

Original languageEnglish
Pages (from-to)196-202
Number of pages7
JournalSeminars in Radiation Oncology
Issue number3
Publication statusPublished - Jul 2011
Externally publishedYes

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