Nelumal A, the active principle of Ligularia nelumbifolia, is a novel aromatase inhibitor

Francesco Epifano; Salvatore Genovese; Serena Fiorito; Chantal Magne Nde; Colin Clyne

Nelumal A, the active principle of Ligularia nelumbifolia, is a novel aromatase inhibitor

Francesco Epifano, Salvatore Genovese, Serena Fiorito, Chantal Magne Nde, Colin Clyne

Biochemistry & Molecular Biology

Research output: Contribution to journal › Article › Other › peer-review

4 Citations (Scopus)

Abstract

Nelumal A, the active principle of Ligularia nelumbifolia was preliminarily tested as an aromatase inhibitors in HEK293 cells transfected with aromatase cDNA and using anastrazole as the reference drug. This screening revealed that it showed an appreciable level of inhibition. Subsequent experiments aimed to evaluate the aromatase activity and expression in KGN cells confirmed that the title natural product, after an incubation of 48 h, compared favourably with anastrazole (1 μM) in the concentration range 10-30 μM. Moreover, nelumal A (30 μM) abolished the aromatase mRNA expression in the same cell line.

Original language	English
Pages (from-to)	823 - 824
Number of pages	2
Journal	Natural Product Communications
Volume	9
Issue number	6
Publication status	Published - 2014

Keywords

Aromatase inhibitors
Ligularia nelumbifolia
Nelumal A
Oxyprenylated secondary metabolites

Cite this

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title = "Nelumal A, the active principle of Ligularia nelumbifolia, is a novel aromatase inhibitor",

abstract = "Nelumal A, the active principle of Ligularia nelumbifolia was preliminarily tested as an aromatase inhibitors in HEK293 cells transfected with aromatase cDNA and using anastrazole as the reference drug. This screening revealed that it showed an appreciable level of inhibition. Subsequent experiments aimed to evaluate the aromatase activity and expression in KGN cells confirmed that the title natural product, after an incubation of 48 h, compared favourably with anastrazole (1 μM) in the concentration range 10-30 μM. Moreover, nelumal A (30 μM) abolished the aromatase mRNA expression in the same cell line.",

keywords = "Aromatase inhibitors, Ligularia nelumbifolia, Nelumal A, Oxyprenylated secondary metabolites",

author = "Francesco Epifano and Salvatore Genovese and Serena Fiorito and Nde, {Chantal Magne} and Colin Clyne",

year = "2014",

language = "English",

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journal = "Natural Product Communications",

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T1 - Nelumal A, the active principle of Ligularia nelumbifolia, is a novel aromatase inhibitor

AU - Epifano, Francesco

AU - Genovese, Salvatore

AU - Fiorito, Serena

AU - Nde, Chantal Magne

AU - Clyne, Colin

PY - 2014

Y1 - 2014

N2 - Nelumal A, the active principle of Ligularia nelumbifolia was preliminarily tested as an aromatase inhibitors in HEK293 cells transfected with aromatase cDNA and using anastrazole as the reference drug. This screening revealed that it showed an appreciable level of inhibition. Subsequent experiments aimed to evaluate the aromatase activity and expression in KGN cells confirmed that the title natural product, after an incubation of 48 h, compared favourably with anastrazole (1 μM) in the concentration range 10-30 μM. Moreover, nelumal A (30 μM) abolished the aromatase mRNA expression in the same cell line.

AB - Nelumal A, the active principle of Ligularia nelumbifolia was preliminarily tested as an aromatase inhibitors in HEK293 cells transfected with aromatase cDNA and using anastrazole as the reference drug. This screening revealed that it showed an appreciable level of inhibition. Subsequent experiments aimed to evaluate the aromatase activity and expression in KGN cells confirmed that the title natural product, after an incubation of 48 h, compared favourably with anastrazole (1 μM) in the concentration range 10-30 μM. Moreover, nelumal A (30 μM) abolished the aromatase mRNA expression in the same cell line.

KW - Aromatase inhibitors

KW - Ligularia nelumbifolia

KW - Nelumal A

KW - Oxyprenylated secondary metabolites

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M3 - Article

C2 - 25115089

SN - 1934-578X

VL - 9

SP - 823

EP - 824

JO - Natural Product Communications

JF - Natural Product Communications

IS - 6

ER -

Nelumal A, the active principle of Ligularia nelumbifolia, is a novel aromatase inhibitor

Abstract

Keywords

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