Nelumal A, the active principle of Ligularia nelumbifolia, is a novel aromatase inhibitor

Francesco Epifano, Salvatore Genovese, Serena Fiorito, Chantal Magne Nde, Colin Clyne

Research output: Contribution to journalArticleOtherpeer-review

1 Citation (Scopus)

Abstract

Nelumal A, the active principle of Ligularia nelumbifolia was preliminarily tested as an aromatase inhibitors in HEK293 cells transfected with aromatase cDNA and using anastrazole as the reference drug. This screening revealed that it showed an appreciable level of inhibition. Subsequent experiments aimed to evaluate the aromatase activity and expression in KGN cells confirmed that the title natural product, after an incubation of 48 h, compared favourably with anastrazole (1 μM) in the concentration range 10-30 μM. Moreover, nelumal A (30 μM) abolished the aromatase mRNA expression in the same cell line.

Original languageEnglish
Pages (from-to)823 - 824
Number of pages2
JournalNatural Product Communications
Volume9
Issue number6
Publication statusPublished - 2014

Keywords

  • Aromatase inhibitors
  • Ligularia nelumbifolia
  • Nelumal A
  • Oxyprenylated secondary metabolites

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