Neither protein kinase C nor adenylate cyclase are altered in the striatum from subjects with schizophrenia

Kenneth Opeskin, Brian Dean, Geoffrey Pavey, Christine Hill, Nicholas Keks, David Copolov

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Dopamine (DA) D2 receptors which act by modulating second messenger pathways that include protein kinase C (PKC) and adenylate cyclase (AC) have been repeatedly shown to be increased in striatum from subjects with schizophrenia. Therefore it seemed possible that chronic up-regulation of DA-D2 receptors in the schizophrenic brain could result in a change in either of these two proteins. Hence we measured PKC and AC in striatum from 20 schizophrenic subjects and 20 non-schizophrenic subjects by quantitative autoradiography and could show no difference in the density of either PKC (436 ± 35 vs. 485 ± 29 fmol/mg tissue equivalents (TE), mean ± SEM) or AC (77 ± 9 vs. 80 ± 7 fmol/mg TE) in the tissue from schizophrenic compared to the non-schizophrenic subjects. Thus, these data do not support the hypothesis that PKC or AC are changed in the schizophrenic brain.

Original languageEnglish
Pages (from-to)159-164
Number of pages6
JournalSchizophrenia Research
Issue number2
Publication statusPublished - 15 Nov 1996


  • [H]forskolin binding
  • [H]pdbu binding
  • adenylate cyclase
  • protein kinase c
  • schizophrenia

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