Neither protein kinase C nor adenylate cyclase are altered in the striatum from subjects with schizophrenia

Kenneth Opeskin; Brian Dean; Geoffrey Pavey; Christine Hill; Nicholas Keks; David Copolov

doi:10.1016/S0920-9964(96)00065-5

Neither protein kinase C nor adenylate cyclase are altered in the striatum from subjects with schizophrenia

Kenneth Opeskin, Brian Dean, Geoffrey Pavey, Christine Hill, Nicholas Keks, David Copolov

Surgery Alfred Hospital

Research output: Contribution to journal › Article › Research › peer-review

7 Citations (Scopus)

Abstract

Dopamine (DA) D2 receptors which act by modulating second messenger pathways that include protein kinase C (PKC) and adenylate cyclase (AC) have been repeatedly shown to be increased in striatum from subjects with schizophrenia. Therefore it seemed possible that chronic up-regulation of DA-D2 receptors in the schizophrenic brain could result in a change in either of these two proteins. Hence we measured PKC and AC in striatum from 20 schizophrenic subjects and 20 non-schizophrenic subjects by quantitative autoradiography and could show no difference in the density of either PKC (436 ± 35 vs. 485 ± 29 fmol/mg tissue equivalents (TE), mean ± SEM) or AC (77 ± 9 vs. 80 ± 7 fmol/mg TE) in the tissue from schizophrenic compared to the non-schizophrenic subjects. Thus, these data do not support the hypothesis that PKC or AC are changed in the schizophrenic brain.

Original language	English
Pages (from-to)	159-164
Number of pages	6
Journal	Schizophrenia Research
Volume	22
Issue number	2
DOIs	https://doi.org/10.1016/S0920-9964(96)00065-5
Publication status	Published - 15 Nov 1996

Keywords

[H]forskolin binding
[H]pdbu binding
adenylate cyclase
protein kinase c
schizophrenia

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0920-9964(96)00065-5

Cite this

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title = "Neither protein kinase C nor adenylate cyclase are altered in the striatum from subjects with schizophrenia",

abstract = "Dopamine (DA) D2 receptors which act by modulating second messenger pathways that include protein kinase C (PKC) and adenylate cyclase (AC) have been repeatedly shown to be increased in striatum from subjects with schizophrenia. Therefore it seemed possible that chronic up-regulation of DA-D2 receptors in the schizophrenic brain could result in a change in either of these two proteins. Hence we measured PKC and AC in striatum from 20 schizophrenic subjects and 20 non-schizophrenic subjects by quantitative autoradiography and could show no difference in the density of either PKC (436 ± 35 vs. 485 ± 29 fmol/mg tissue equivalents (TE), mean ± SEM) or AC (77 ± 9 vs. 80 ± 7 fmol/mg TE) in the tissue from schizophrenic compared to the non-schizophrenic subjects. Thus, these data do not support the hypothesis that PKC or AC are changed in the schizophrenic brain.",

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AU - Keks, Nicholas

AU - Copolov, David

PY - 1996/11/15

Y1 - 1996/11/15

N2 - Dopamine (DA) D2 receptors which act by modulating second messenger pathways that include protein kinase C (PKC) and adenylate cyclase (AC) have been repeatedly shown to be increased in striatum from subjects with schizophrenia. Therefore it seemed possible that chronic up-regulation of DA-D2 receptors in the schizophrenic brain could result in a change in either of these two proteins. Hence we measured PKC and AC in striatum from 20 schizophrenic subjects and 20 non-schizophrenic subjects by quantitative autoradiography and could show no difference in the density of either PKC (436 ± 35 vs. 485 ± 29 fmol/mg tissue equivalents (TE), mean ± SEM) or AC (77 ± 9 vs. 80 ± 7 fmol/mg TE) in the tissue from schizophrenic compared to the non-schizophrenic subjects. Thus, these data do not support the hypothesis that PKC or AC are changed in the schizophrenic brain.

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KW - [H]pdbu binding

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Neither protein kinase C nor adenylate cyclase are altered in the striatum from subjects with schizophrenia

Abstract

Keywords

UN SDGs

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