Negative correlation between circulating Cd4+Foxp3+Cd127 regulatory T Cells and subsequent antibody responses to infant measles vaccine but not diphtheria–tetanus–pertussis vaccine implies a regulatory role

Jorjoh Ndure, Fatou Noho-Konteh, Jane U. Adetifa, Momodou Cox, Peter Francis Barker, My Thanh Le, Lady Chilel Sanyang, Adboulie Drammeh, Hilton C Whittle, Ed Clarke, Magdalena Plebanski, Sarah L Rowland-Jones, Katie L. Flanagan

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Abstract

Regulatory T cells (Tregs) play a key homeostatic role by suppressing immune responses. They have been targeted in mouse and human cancer studies to improve vaccine immunogenicity and tumor clearance. A number of commercially available drugs and experimental vaccine adjuvants have been shown to target Tregs. Infants have high numbers of Tregs and often have poor responses to vaccination, yet the role Tregs play in controlling vaccine immunogenicity has not been explored in this age group. Herein, we explore the role of CD4+FOXP3+CD127 Tregs in controlling immunity in infant males and females to vaccination with diphtheria–tetanus–whole cell pertussis (DTP) and/or measles vaccine (MV). We find correlative evidence that circulating Tregs at the time of vaccination suppress antibody responses to MV but not DTP; and Tregs 4 weeks after DTP vaccination may suppress vaccine-specific cellular immunity. This opens the exciting possibility that Tregs may provide a future target for improved vaccine responses in early life, including reducing the number of doses of vaccine required. Such an approach would need to be safe and the benefits outweigh the risks, thus further research in this area is required.

Original languageEnglish
Article number921
Number of pages12
JournalFrontiers in Immunology
Volume8
Issue numberAUG
DOIs
Publication statusPublished - 14 Aug 2017

Keywords

  • Antibodies
  • Beta-2 microglobulin
  • Cytokines
  • Immune activation
  • Regulatory T cells
  • Sex
  • Vaccines

Cite this

Ndure, Jorjoh ; Noho-Konteh, Fatou ; Adetifa, Jane U. ; Cox, Momodou ; Barker, Peter Francis ; Le, My Thanh ; Sanyang, Lady Chilel ; Drammeh, Adboulie ; Whittle, Hilton C ; Clarke, Ed ; Plebanski, Magdalena ; Rowland-Jones, Sarah L ; Flanagan, Katie L. / Negative correlation between circulating Cd4+Foxp3+Cd127 regulatory T Cells and subsequent antibody responses to infant measles vaccine but not diphtheria–tetanus–pertussis vaccine implies a regulatory role. In: Frontiers in Immunology. 2017 ; Vol. 8, No. AUG.
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abstract = "Regulatory T cells (Tregs) play a key homeostatic role by suppressing immune responses. They have been targeted in mouse and human cancer studies to improve vaccine immunogenicity and tumor clearance. A number of commercially available drugs and experimental vaccine adjuvants have been shown to target Tregs. Infants have high numbers of Tregs and often have poor responses to vaccination, yet the role Tregs play in controlling vaccine immunogenicity has not been explored in this age group. Herein, we explore the role of CD4+FOXP3+CD127− Tregs in controlling immunity in infant males and females to vaccination with diphtheria–tetanus–whole cell pertussis (DTP) and/or measles vaccine (MV). We find correlative evidence that circulating Tregs at the time of vaccination suppress antibody responses to MV but not DTP; and Tregs 4 weeks after DTP vaccination may suppress vaccine-specific cellular immunity. This opens the exciting possibility that Tregs may provide a future target for improved vaccine responses in early life, including reducing the number of doses of vaccine required. Such an approach would need to be safe and the benefits outweigh the risks, thus further research in this area is required.",
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Negative correlation between circulating Cd4+Foxp3+Cd127 regulatory T Cells and subsequent antibody responses to infant measles vaccine but not diphtheria–tetanus–pertussis vaccine implies a regulatory role. / Ndure, Jorjoh; Noho-Konteh, Fatou; Adetifa, Jane U.; Cox, Momodou; Barker, Peter Francis; Le, My Thanh; Sanyang, Lady Chilel; Drammeh, Adboulie; Whittle, Hilton C; Clarke, Ed; Plebanski, Magdalena; Rowland-Jones, Sarah L; Flanagan, Katie L.

In: Frontiers in Immunology, Vol. 8, No. AUG, 921, 14.08.2017.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Ndure, Jorjoh

AU - Noho-Konteh, Fatou

AU - Adetifa, Jane U.

AU - Cox, Momodou

AU - Barker, Peter Francis

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AU - Sanyang, Lady Chilel

AU - Drammeh, Adboulie

AU - Whittle, Hilton C

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AU - Rowland-Jones, Sarah L

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AB - Regulatory T cells (Tregs) play a key homeostatic role by suppressing immune responses. They have been targeted in mouse and human cancer studies to improve vaccine immunogenicity and tumor clearance. A number of commercially available drugs and experimental vaccine adjuvants have been shown to target Tregs. Infants have high numbers of Tregs and often have poor responses to vaccination, yet the role Tregs play in controlling vaccine immunogenicity has not been explored in this age group. Herein, we explore the role of CD4+FOXP3+CD127− Tregs in controlling immunity in infant males and females to vaccination with diphtheria–tetanus–whole cell pertussis (DTP) and/or measles vaccine (MV). We find correlative evidence that circulating Tregs at the time of vaccination suppress antibody responses to MV but not DTP; and Tregs 4 weeks after DTP vaccination may suppress vaccine-specific cellular immunity. This opens the exciting possibility that Tregs may provide a future target for improved vaccine responses in early life, including reducing the number of doses of vaccine required. Such an approach would need to be safe and the benefits outweigh the risks, thus further research in this area is required.

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KW - Sex

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