TY - JOUR
T1 - Near-infrared spectroscopy parameters in patients undergoing continuous venovenous hemodiafiltration
AU - Chaves, Renato Carneiro de Freitas
AU - Tafner, Philipe Franco do Amaral
AU - Chen, Felipe Ko
AU - Meneghini, Letícia Bagatini
AU - Corrêa, Thiago Domingos
AU - Rabello Filho, Roberto
AU - Cendoroglo Neto, Miguel
AU - Santos, Oscar Fernando Pavão Dos
AU - Serpa Neto, Ary
PY - 2019/1
Y1 - 2019/1
N2 - OBJECTIVE: To investigate the impacts of continuous venovenous hemodiafiltration on the microcirculation in patients with acute kidney injury. METHODS: A prospective observational pilot study conducted in a 40-bed, open clinical-surgical intensive care unit of a private tertiary care hospital located in the city of São Paulo (SP), Brazil. Microcirculation was assessed using near-infrared spectroscopy by means of a 15mm probe placed over the thenar eminence. Vascular occlusion test was performed on the forearm to be submitted to near-infrared spectroscopy by inflation of a sphygmomanometer cuff to 30mmHg higher than the systolic arterial pressure. The primary endpoint was the assessment of near-infrared spectroscopy-derived parameters immediately before, 1, 4 and 24 hours after the initiation of continuous venovenous hemodiafiltration. RESULTS: Nine patients were included in this pilot study over a period of 2 months. Minimum tissue oxygen saturation measured during the vascular occlusion test was the only near-infrared spectroscopy-derived parameter to differed over the time (decrease compared to baseline values up to 24 hours after initiation of continuous venovenous hemodiafiltration). CONCLUSION: The impacts of microcirculatory dysfunction on clinical outcomes of patients undergoing to continuous venovenous hemodiafiltration need to be further investigated.
AB - OBJECTIVE: To investigate the impacts of continuous venovenous hemodiafiltration on the microcirculation in patients with acute kidney injury. METHODS: A prospective observational pilot study conducted in a 40-bed, open clinical-surgical intensive care unit of a private tertiary care hospital located in the city of São Paulo (SP), Brazil. Microcirculation was assessed using near-infrared spectroscopy by means of a 15mm probe placed over the thenar eminence. Vascular occlusion test was performed on the forearm to be submitted to near-infrared spectroscopy by inflation of a sphygmomanometer cuff to 30mmHg higher than the systolic arterial pressure. The primary endpoint was the assessment of near-infrared spectroscopy-derived parameters immediately before, 1, 4 and 24 hours after the initiation of continuous venovenous hemodiafiltration. RESULTS: Nine patients were included in this pilot study over a period of 2 months. Minimum tissue oxygen saturation measured during the vascular occlusion test was the only near-infrared spectroscopy-derived parameter to differed over the time (decrease compared to baseline values up to 24 hours after initiation of continuous venovenous hemodiafiltration). CONCLUSION: The impacts of microcirculatory dysfunction on clinical outcomes of patients undergoing to continuous venovenous hemodiafiltration need to be further investigated.
KW - spectroscopy, near infrared
KW - Microcirculation
KW - Oxygenation
KW - Hemodynamics
KW - Acute kidney injuries
KW - Renal replacement therapy
KW - Critical care
UR - http://www.scopus.com/inward/record.url?scp=85061845996&partnerID=8YFLogxK
U2 - 10.31744/einstein_journal/2019AO4439
DO - 10.31744/einstein_journal/2019AO4439
M3 - Article
C2 - 30785493
AN - SCOPUS:85061845996
SN - 1679-4508
VL - 17
JO - Einstein
JF - Einstein
IS - 1
M1 - eAO4439
ER -