Navigating the future of bacterial molecular epidemiology

Stephen Baker, William P. Hanage, Kathryn E. Holt

Research output: Contribution to journalReview ArticleResearchpeer-review

44 Citations (Scopus)

Abstract

Technological advances in high-throughput genome sequencing have led to an enhanced appreciation of the genetic diversity found within populations of pathogenic bacteria. Methods based on single nucleotide polymorphisms (SNPs) and insertions or deletions (indels) build upon the framework established by multi-locus sequence typing (MLST) and permit a detailed, targeted analysis of variation within related organisms. Robust phylogenetics, when combined with epidemiologically informative data, can be applied to study ongoing temporal and geographical fluctuations in bacterial pathogens. As genome sequencing, SNP detection and geospatial information become more accessible these methods will continue to transform the way molecular epidemiology is used to study populations of bacterial pathogens.

Original languageEnglish
Pages (from-to)640-645
Number of pages6
JournalCurrent Opinion in Microbiology
Volume13
Issue number5
DOIs
Publication statusPublished - 1 Oct 2010
Externally publishedYes

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