TY - JOUR
T1 - "Natural Regulators"
T2 - NK cells as modulators of T cell immunity
AU - Schuster, Iona S.
AU - Coudert, Jerome D.
AU - Andoniou, Christopher E.
AU - Degli-Esposti, Mariapia A.
PY - 2016/6/14
Y1 - 2016/6/14
N2 - Natural killer (NK) cells are known as frontline responders capable of rapidly mediating a response upon encountering transformed or infected cells. Recent findings indicate that NK cells, in addition to acting as innate effectors, can also regulate adaptive immune responses. Here, we review recent studies on the immunoregulatory function of NK cells with a specific focus on their ability to affect the generation of early, as well as long-term antiviral T cell responses, and their role in modulating immune pathology and disease. In addition, we summarize the current knowledge of the factors governing regulatory NK cell responses and discuss origin, tissue specificity, and open questions about the classification of regulatory NK cells as classical NK cells versus group 1 innate lymphoid cells.
AB - Natural killer (NK) cells are known as frontline responders capable of rapidly mediating a response upon encountering transformed or infected cells. Recent findings indicate that NK cells, in addition to acting as innate effectors, can also regulate adaptive immune responses. Here, we review recent studies on the immunoregulatory function of NK cells with a specific focus on their ability to affect the generation of early, as well as long-term antiviral T cell responses, and their role in modulating immune pathology and disease. In addition, we summarize the current knowledge of the factors governing regulatory NK cell responses and discuss origin, tissue specificity, and open questions about the classification of regulatory NK cells as classical NK cells versus group 1 innate lymphoid cells.
KW - Adaptive immunity
KW - ILC
KW - Immune regulation
KW - NK cells
KW - Viral infection
UR - http://www.scopus.com/inward/record.url?scp=84977504537&partnerID=8YFLogxK
U2 - 10.3389/fimmu.2016.00235
DO - 10.3389/fimmu.2016.00235
M3 - Short Survey
AN - SCOPUS:84977504537
SN - 1664-3224
VL - 7
JO - Frontiers in Immunology
JF - Frontiers in Immunology
IS - JUN
M1 - 235
ER -