Natural occurrence of 2-5A in interferon-treated EMC virus-infected L cells

B. R.G. Williams; R. R. Golgher; R. E. Brown; C. S. Gilbert; I. M. Kerr

doi:10.1038/282582a0

Natural occurrence of 2-5A in interferon-treated EMC virus-infected L cells

B. R.G. Williams, R. R. Golgher, R. E. Brown, C. S. Gilbert, I. M. Kerr

Research output: Contribution to journal › Article › Research › peer-review

185 Citations (Scopus)

Abstract

Until now the inierfer on-mediated 2′-5′ adenine oligonucleotide inhibitors (2-5A) of cell-free protein synthesis have not been detected in intact cells. Here we report their natural occurrence in interferon-treated, EMC virus-infected mouse L cells in amounts consistent with the idea that they play a part in the inhibition of virus growth.

Original language	English
Pages (from-to)	582-586
Number of pages	5
Journal	Nature
Volume	282
Issue number	5739
DOIs	https://doi.org/10.1038/282582a0
Publication status	Published - 1 Dec 1979
Externally published	Yes

Access to Document

10.1038/282582a0

Cite this

@article{18270063f6bb4888899516e58c91e6f8,

title = "Natural occurrence of 2-5A in interferon-treated EMC virus-infected L cells",

abstract = "Until now the inierfer on-mediated 2′-5′ adenine oligonucleotide inhibitors (2-5A) of cell-free protein synthesis have not been detected in intact cells. Here we report their natural occurrence in interferon-treated, EMC virus-infected mouse L cells in amounts consistent with the idea that they play a part in the inhibition of virus growth.",

author = "Williams, {B. R.G.} and Golgher, {R. R.} and Brown, {R. E.} and Gilbert, {C. S.} and Kerr, {I. M.}",

year = "1979",

month = dec,

day = "1",

doi = "10.1038/282582a0",

language = "English",

volume = "282",

pages = "582--586",

journal = "Nature",

issn = "0028-0836",

publisher = "Nature Publishing Group",

number = "5739",

}

TY - JOUR

T1 - Natural occurrence of 2-5A in interferon-treated EMC virus-infected L cells

AU - Williams, B. R.G.

AU - Golgher, R. R.

AU - Brown, R. E.

AU - Gilbert, C. S.

AU - Kerr, I. M.

PY - 1979/12/1

Y1 - 1979/12/1

N2 - Until now the inierfer on-mediated 2′-5′ adenine oligonucleotide inhibitors (2-5A) of cell-free protein synthesis have not been detected in intact cells. Here we report their natural occurrence in interferon-treated, EMC virus-infected mouse L cells in amounts consistent with the idea that they play a part in the inhibition of virus growth.

AB - Until now the inierfer on-mediated 2′-5′ adenine oligonucleotide inhibitors (2-5A) of cell-free protein synthesis have not been detected in intact cells. Here we report their natural occurrence in interferon-treated, EMC virus-infected mouse L cells in amounts consistent with the idea that they play a part in the inhibition of virus growth.

UR - http://www.scopus.com/inward/record.url?scp=0018706198&partnerID=8YFLogxK

U2 - 10.1038/282582a0

DO - 10.1038/282582a0

M3 - Article

C2 - 95208

AN - SCOPUS:0018706198

SN - 0028-0836

VL - 282

SP - 582

EP - 586

JO - Nature

JF - Nature

IS - 5739

ER -

Natural occurrence of 2-5A in interferon-treated EMC virus-infected L cells

Abstract

Access to Document

Other files and links

Cite this