TY - JOUR
T1 - Natural killer cell heterogeneity
T2 - Cellular dysfunction and significance in HIV-1 immuno-pathogenesis
AU - Ansari, A. Wahid
AU - Ahmad, Fareed
AU - Meyer-Olson, Dirk
AU - Kamarulzaman, Adeeba
AU - Jacobs, Roland
AU - Schmidt, Reinhold E.
N1 - Funding Information:
The authors would like to thank Dr. Scott Hale, Emory University School of Medicine, USA for critically reading the manuscript. This study was supported by the University of Malaya Research Grant (RG 501-13HTM) of the Health and Translational Medicine Cluster awarded to AWA, and DMO received funding from Bundesministerium fur Bildung und Forschung, and DZIF TTU 04.802, Germany.
Publisher Copyright:
© 2015 Springer Basel.
PY - 2015/8/25
Y1 - 2015/8/25
N2 - Natural killer (NK) cells are innate immune effectors that provide first line of defence against viruses. Human NK cells are heterogeneous in nature, and their functions rely on a dynamic balance between germ-line-encoded activating and inhibitory receptors. HIV-1 infection results in altered NK cell receptor repertoire and impaired effector functions including the ability to lyse virus-infected cells and secretion of antiviral cytokine IFN-γ. Over the last decade, additional NK cell subset-specific molecules have been identified, leading to emergence of a more complex cellular diversity than previously thought. Herein, we discuss NK cell subset redistribution, altered receptor repertoire and influence of interaction of polymorphic leucocyte antigen (HLA) and killer cell immunoglobulin-like receptors (KIR) on HIV-1 disease progression.
AB - Natural killer (NK) cells are innate immune effectors that provide first line of defence against viruses. Human NK cells are heterogeneous in nature, and their functions rely on a dynamic balance between germ-line-encoded activating and inhibitory receptors. HIV-1 infection results in altered NK cell receptor repertoire and impaired effector functions including the ability to lyse virus-infected cells and secretion of antiviral cytokine IFN-γ. Over the last decade, additional NK cell subset-specific molecules have been identified, leading to emergence of a more complex cellular diversity than previously thought. Herein, we discuss NK cell subset redistribution, altered receptor repertoire and influence of interaction of polymorphic leucocyte antigen (HLA) and killer cell immunoglobulin-like receptors (KIR) on HIV-1 disease progression.
KW - Antibody-dependent cellular cytotoxicity
KW - CD56 dim and bright
KW - Granzyme B
KW - Highly active antiretroviral therapy
KW - Innate immunity
UR - http://www.scopus.com/inward/record.url?scp=84937974362&partnerID=8YFLogxK
U2 - 10.1007/s00018-015-1911-5
DO - 10.1007/s00018-015-1911-5
M3 - Review Article
C2 - 25939268
AN - SCOPUS:84937974362
SN - 1420-682X
VL - 72
SP - 3037
EP - 3049
JO - Cellular and Molecular Life Sciences
JF - Cellular and Molecular Life Sciences
IS - 16
ER -
