Natural IgE production in the absence of MHC class II cognate help

Kathy D. McCoy, Nicola L. Harris, Philipp Diener, Sarah Hatak, Bernhard Odermatt, Lars Hangartner, Beatrice M. Senn, Benjamin J. Marsland, Markus B. Geuking, Hans Hengartner, Andrew J S Macpherson, Rolf M. Zinkernagel

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84 Citations (Scopus)

Abstract

IgE induction by parasites and allergens is antigen driven and cognate T cell help dependent. We demonstrate that spontaneously produced IgE in T cell-deficient and germ-free wild-type (wt) mice is composed of natural specificities and induced by a mechanism independent of MHC class II (MHC II) cognate help. This does not require secondary lymphoid structures or germinal center formation, although some bystander T cell-derived IL-4 is necessary. The pathway of spontaneous IgE production is not inhibited by regulatory T cells and increases with age to constitute significant serum concentrations, even in naive animals.

Original languageEnglish
Pages (from-to)329-339
Number of pages11
JournalImmunity
Volume24
Issue number3
DOIs
Publication statusPublished - 1 Mar 2006
Externally publishedYes

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