There are conflicting data on the natural history and clinical significance of bone marrow lesions (BMLs). The aims of this study were to describe the natural history of MRI-detected BMLs at the knee using a quantitative measure and examine the association of BMLs with pain, function and stiffness scores, and total knee replacement (TKR) surgery.
Dore, D., Quinn, S., Ding, C., Winzenberg, T., Zhai, G., Cicuttini, F., & Jones, G. (2010). Natural history and clinical significance of MRI-detected bone marrow lesions at the knee: A prospective study in community dwelling older adults. Arthritis Research & Therapy, 12(6), 1 - 12. https://doi.org/10.1186/ar3210