Nanotechnological advances in the treatment of epilepsy

Ola Asem Mahmoud Abdou Ali, Mohd. Farooq Shaikh, M. Saquib Hasnain, Farheen Sami, Abdullah Khan, Mohammed Tahir Ansari

Research output: Contribution to journalReview ArticleResearchpeer-review

7 Citations (Scopus)

Abstract

Epilepsy is known as one of the major challenges for medical science. The sudden ap-pearance of a seizure has been a significant health emergency as it may lead to further complica-tions. Although key advancements have been achieved in terms of pharmacological approaches for epilepsy, many issues remain uncertain. Lipid carriers have been at the forefront, especially in neu-rodegenerative diseases, such as epilepsy, Alzheimer’s, dementia, etc. The blood-brain barrier still appears to be a major impediment in the successful treatment of epileptic seizures. This is mainly due to the limited bioavailability of most anti-convulsant drugs. The present review encompasses the issues underlying the current approach for epilepsy drug treatment and highlights the newer, novel, and more precise drug delivery system to manage seizures. The advantage of using a lipid-based delivery system is its superior absorption in the brain cells. Ample evidence shows that reduc-ing the particle size also infuses the drug easily through the blood-brain barrier. The application of liposomes, polymeric nanoparticles, metallic nanoparticles, and solid lipid nanoparticles for the treatment and management of epilepsy has been highlighted in the present review. This review pro-vides an overview of the current status of the treatment and recent advances in the treatment of epilepsy.

Original languageEnglish
Pages (from-to)994-1003
Number of pages10
JournalCNS & Neurological Disorders - Drug Targets
Volume21
Issue number10
DOIs
Publication statusPublished - Dec 2022

Keywords

  • blood brain barrier
  • Epilepsy
  • liposomes
  • metallic
  • nanoparticles
  • resistance

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