Nanostructured silicalipid hybrid microparticles: A supersaturating carrier for water- and lipid-resistant compounds

Angel Tan, Clive Prestidge

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Abstract

Nanostructured silicalipid hybrid (SLH) microparticles, which are fabricated based on Pickering emulsion templates, are reported to enhance the encapsulation efficiency of a weak base anthelmintic, albendazole (ABZ). ABZ exhibits poor solubility in aqueous solutions and in commonly used pharmaceutical surfactants and oils. The encapsulation of ABZSLH in a supersaturated but noncrystalline form was shown to enhance its dissolution kinetics (up to tenfold) in simulated gastric fluids, regardless of the presence of sink conditions that were representative of the influence of food intake.

Original languageEnglish
Pages (from-to)1334-1336
Number of pages3
JournalChemistry Letters
Volume41
Issue number10
DOIs
Publication statusPublished - 2012
Externally publishedYes

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