Nanostructured liquid crystalline particles provide long duration sustained-release effect for a poorly water soluble drug after oral administration

Tri-Hung Nguyen; Tracey Hanley; Christopher Porter; Benjamin Boyd

doi:10.1016/j.jconrel.2011.03.033

Nanostructured liquid crystalline particles provide long duration sustained-release effect for a poorly water soluble drug after oral administration

Tri-Hung Nguyen
, Tracey Hanley
, Christopher Porter
, Benjamin Boyd

Drug Delivery Disposition & Dynamics

Research output: Contribution to journal › Article › Research › peer-review

194 Citations (Scopus)

Abstract

This study is the first to demonstrate the ability of nanostructured liquid crystal particles to sustain the absorption of a poorly water soluble drug after oral administration. Cubic (V2) liquid crystalline nanostructured particles (cubosomes) formed from phytantriol (PHY) were shown to sustain the absorption of cinnarizine (CZ) beyond 48 h after oral administration to rats.

Original language	English
Pages (from-to)	180 - 186
Number of pages	7
Journal	Journal of Controlled Release
Volume	153
DOIs	https://doi.org/10.1016/j.jconrel.2011.03.033
Publication status	Published - 2011

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10.1016/j.jconrel.2011.03.033

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title = "Nanostructured liquid crystalline particles provide long duration sustained-release effect for a poorly water soluble drug after oral administration",

abstract = "This study is the first to demonstrate the ability of nanostructured liquid crystal particles to sustain the absorption of a poorly water soluble drug after oral administration. Cubic (V2) liquid crystalline nanostructured particles (cubosomes) formed from phytantriol (PHY) were shown to sustain the absorption of cinnarizine (CZ) beyond 48 h after oral administration to rats.",

author = "Tri-Hung Nguyen and Tracey Hanley and Christopher Porter and Benjamin Boyd",

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doi = "10.1016/j.jconrel.2011.03.033",

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AU - Nguyen, Tri-Hung

AU - Hanley, Tracey

AU - Porter, Christopher

AU - Boyd, Benjamin

PY - 2011

Y1 - 2011

N2 - This study is the first to demonstrate the ability of nanostructured liquid crystal particles to sustain the absorption of a poorly water soluble drug after oral administration. Cubic (V2) liquid crystalline nanostructured particles (cubosomes) formed from phytantriol (PHY) were shown to sustain the absorption of cinnarizine (CZ) beyond 48 h after oral administration to rats.

AB - This study is the first to demonstrate the ability of nanostructured liquid crystal particles to sustain the absorption of a poorly water soluble drug after oral administration. Cubic (V2) liquid crystalline nanostructured particles (cubosomes) formed from phytantriol (PHY) were shown to sustain the absorption of cinnarizine (CZ) beyond 48 h after oral administration to rats.

UR - http://www.sciencedirect.com/science/article/pii/S0168365911002173

U2 - 10.1016/j.jconrel.2011.03.033

DO - 10.1016/j.jconrel.2011.03.033

M3 - Article

SN - 0168-3659

VL - 153

SP - 180

EP - 186

JO - Journal of Controlled Release

JF - Journal of Controlled Release

ER -

Nanostructured liquid crystalline particles provide long duration sustained-release effect for a poorly water soluble drug after oral administration

Abstract

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