Nanostructured liquid crystalline particles provide long duration sustained-release effect for a poorly water soluble drug after oral administration

Tri-Hung Nguyen, Tracey Hanley, Christopher Porter, Benjamin Boyd

Research output: Contribution to journalArticleResearchpeer-review

140 Citations (Scopus)

Abstract

This study is the first to demonstrate the ability of nanostructured liquid crystal particles to sustain the absorption of a poorly water soluble drug after oral administration. Cubic (V2) liquid crystalline nanostructured particles (cubosomes) formed from phytantriol (PHY) were shown to sustain the absorption of cinnarizine (CZ) beyond 48 h after oral administration to rats.
Original languageEnglish
Pages (from-to)180 - 186
Number of pages7
JournalJournal of Controlled Release
Volume153
DOIs
Publication statusPublished - 2011

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