Nanoparticles: Important Tools to Overcome the Blood-Brain Barrier and Their Use for Brain Imaging

Ruirui Qiao, Mingyuan Gao, Hans Joachim Galla

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

2 Citations (Scopus)


Nanoparticles are important tools for brain disease diagnoses and treatment. In both cases, either used for imaging or for the transfer of drugs, they have to cross the blood-brain or the blood-cerebrospinal fluid (CSF) barrier in order to reach the brain parenchyma. The endothelial cells of the cerebral microvessels form the so-called blood-brain barrier (BBB). The BBB is located within the cerebral capillaries and is formed by the endothelial cells lining the vessel wall. Different neuroinvasive strategies have been applied to enhance the brain uptake of therapeutic drugs, including direct injection into the parenchyma, implantation of drug-loaded polymeric matrices, polymeric wafers, and microcapsules with controlled release. Nanoparticles may be classified by their chemical nature into organic and inorganic carriers. For brain disease imaging, magnetic resonance imaging (MRI) is one of the primary imaging modalities used in the clinic for providing high spatial and temporal resolution.

Original languageEnglish
Title of host publicationSoft Matter Nanotechnology
Subtitle of host publicationFrom Structure to Function
EditorsXiaodong Chen, Harald Fuchs
Place of PublicationWeinheim Germany
PublisherWiley-VCH Verlag GmbH & Co. KGaA
Number of pages22
ISBN (Electronic)9783527682140, 9783527682164, 9783527682133, 9783527682157
ISBN (Print)9783527337224
Publication statusPublished - 1 Jan 2015
Externally publishedYes


  • Blood-brain barrier
  • Blood-cerebrospinal fluid barrier
  • Brain imaging
  • Brain uptake
  • Magnetic resonance imaging
  • Nanoparticles

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