Nanoparticle-Proteome In Vitro and In Vivo

Miaoyi Wang, Ove J. R. Gustafsson, Emily H Pilkington, Aleksandr Kakinen, Ibrahim Javed, Ava Faridi, Thomas P Davis, Pu Chun Ke

Research output: Contribution to journalReview ArticleResearchpeer-review

9 Citations (Scopus)

Abstract

The protein corona is a concept central to a range of disciplines exploiting the bio-nano interface. As literature continues to expand in this field, it is essential to condense and contextualize the in vitro and in vivo proteome databases accumulated over the past decade: a goal which this review intends to achieve for the benefit of nanomedicine and nanobiotechnology. The parameters used for our review are the physicochemical characteristics of the nanoparticles, their surface ligands, the biological matrix from which a corona was formed, methods employed, plus the top-ten enriched corona proteins. In addition, the protein coronal networks and their implications in vivo are highlighted for selected studies.
Original languageEnglish
Pages (from-to)6026-6041
Number of pages16
JournalJournal of Materials Chemistry B
Volume6
Issue number38
DOIs
Publication statusPublished - 1 Jan 2018

Keywords

  • Protein corona
  • nanoparticles
  • in vitro
  • in vivo
  • proteomics

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