Nanoparticle-based therapy in genomics

Mahmood Rasool, Arif Malik, Abdul Manan, Shakeel Ahmed Ansari, Muhammad Imran Naseer, Mahmood Husain Qazi, Muhammad Asif, Siew Hua Gan, Mohammad Amjad Kamal

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Abstract

In the modern era, humankind is making daily progress through industrialization. As various types of diseases are prevailing worldwide, scientists are using many approaches to manage these diseases, such as gene therapy. A nanoparticle (NP)-based approach is an example of a modern method used to address several pathologies. This modern therapeutic approach aims not only at safely transferring the drug of choice to the site of interest in a biological system but also at ensuring the biocompatibility of these NPs. Hence, various coating methodologies are being employed to avoid NP toxicity as well as immunoreactivity. This short review covers the latest approaches and advances in this biomedical field. Among nanomaterials, gold NPs (GNPs) are comprehensively employed as a diagnostic tool for the treatment and management of diseases such as cancer.

Original languageEnglish
Pages (from-to)354-361
Number of pages8
JournalCurrent Drug Metabolism
Volume16
Issue number5
DOIs
Publication statusPublished - 1 Jun 2015
Externally publishedYes

Keywords

  • Cancer
  • Diseases
  • Gene therapy
  • Gold nanoparticles
  • Health
  • Nanoparticles

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