Nano-chemotherapeutics: Maximising lymphatic drug exposure to improve the treatment of lymph-metastatic cancers

Gemma Ryan, Lisa Michelle Kaminskas, Christopher John Porter

Research output: Contribution to journalArticleResearchpeer-review

55 Citations (Scopus)

Abstract

Nano-sized drug delivery systems incorporating chemotherapeutic drugs ( nano-chemotherapeutics ) have been widely employed for the treatment of solid tumours. The dimensions of nanoparticulate drug delivery systems also make them ideal vectors for improving drug exposure to the lymphatic system, potentially enhancing the treatment of lymph-resident metastases. This review examines the physical properties of nanoparticulate drug delivery systems that promote lymphatic exposure and lymph node retention, and discusses methods for improving lymphatic access. Drug delivery systems that have been investigated for the treatment of lymph node metastasis are also reviewed, and recent advances towards active targeting approaches for lymphatic metastases highlighted.
Original languageEnglish
Pages (from-to)241-256
Number of pages16
JournalJournal of Controlled Release
Volume193
DOIs
Publication statusPublished - 2014

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