NAD(P)H oxidase isoforms as therapeutic targets for diabetic complications

Research output: Contribution to journalReview ArticleResearchpeer-review

1 Citation (Scopus)

Abstract

The development of macro- and microvascular complications is accelerated in diabetic patients. While some therapeutic regimes have helped in delaying progression of complications, none have yet been able to halt the progression and prevent vascular disease, highlighting the need to identify new therapeutic targets. Increased oxidative stress derived from the NADPH oxidase (Nox) family has recently been identified to play an important role in the pathophysiology of vascular disease. In recent years, specific Nox isoforms have been implicated in contributing to the development of atherosclerosis of major vessels, as well as damage of the small vessels within the kidney and the eye. With the use of novel Nox inhibitors, it has been demonstrated that these complications can be attenuated, indicating that targeting Nox derived oxidative stress holds potential as a new therapeutic strategy.

Original languageEnglish
Pages (from-to)111-122
Number of pages12
JournalExpert Review of Endocrinology and Metabolism
Volume9
Issue number2
DOIs
Publication statusPublished - Mar 2014
Externally publishedYes

Keywords

  • Retinopathy
  • cardiovascular disease
  • atherosclerosis
  • diabetes
  • NADPH oxidase
  • nephropathy
  • oxidative stress

Cite this

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title = "NAD(P)H oxidase isoforms as therapeutic targets for diabetic complications",
abstract = "The development of macro- and microvascular complications is accelerated in diabetic patients. While some therapeutic regimes have helped in delaying progression of complications, none have yet been able to halt the progression and prevent vascular disease, highlighting the need to identify new therapeutic targets. Increased oxidative stress derived from the NADPH oxidase (Nox) family has recently been identified to play an important role in the pathophysiology of vascular disease. In recent years, specific Nox isoforms have been implicated in contributing to the development of atherosclerosis of major vessels, as well as damage of the small vessels within the kidney and the eye. With the use of novel Nox inhibitors, it has been demonstrated that these complications can be attenuated, indicating that targeting Nox derived oxidative stress holds potential as a new therapeutic strategy.",
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NAD(P)H oxidase isoforms as therapeutic targets for diabetic complications. / Gray, Stephen P.; Jha, Jay C.; Di Marco, Elyse; Jandeleit-Dahm, Karin Am.

In: Expert Review of Endocrinology and Metabolism, Vol. 9, No. 2, 03.2014, p. 111-122.

Research output: Contribution to journalReview ArticleResearchpeer-review

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