N348I in HIV-1 reverse transcriptase decreases susceptibility to tenofovir and etravirine in combination with other resistance mutations

Nicolas Sluis-Cremer, Katie Moore, Jessica Radzio, Secondo Sonza, Gilda Tachedjian

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Abstract

We previously demonstrated that N348I in HIV-1 reverse transcriptase confers zidovudine and nevirapine resistance. However, both of these inhibitors are currently infrequently used in developed countries, and the impact of N348I on newer reverse transcriptase inhibitors, such as tenofovir and etravirine, is unknown. In this study, we demonstrate that N348I alone confers no resistance to tenofovir and low-level resistance to etravirine. However, N348I significantly decreases tenofovir susceptibility when combined with thymidine analogue mutations and etravirine susceptibility when combined with Y181C.
Original languageEnglish
Pages (from-to)317 - 319
Number of pages3
JournalAIDS
Volume24
Issue number2
DOIs
Publication statusPublished - 2010

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