N-Piperonyl analogue of the atypical antipsychotic clozapine

Ben Capuano, Ian T Crosby, Robert W Gable, Edward J Lloyd

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)


The crystal structure of 11-[4-(1,3-benzodioxol-5-ylmethyl)-piperazino]-8-chloro-5H-dibenzo[b,e]1,4] diazepine, C25H23-ClN4O2, confirms the buckled nature of the dibenzodiazepine nucleus, with the central seven-membered heterocycle in a boat conformation and the dihedral angle between the planes of the aromatic rings being similar to that found for the parent compound, clozapine. The piperazine ring displays an almost perfect chair conformation, with the piperonyl group assuming an equatorial orientation. The relative position of the dibenzodiazepine and piperazine ring systems is controlled by the planarity of the piperazine N atom in the amidine moiety.

Original languageEnglish
Pages (from-to)339-340
Number of pages2
JournalActa Crystallographica Section C: Crystal Structure Communications
Issue number3
Publication statusPublished - 1 Jan 2000

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