N-Heterocyclic Carbene Catalyzed Transformylation

Jared E.M. Fernando, Alison Levens, Daniel Moock, David W. Lupton

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Abstract

The N-heterocyclic carbene (NHC) catalyzed transformylation has been developed for the conversion of 1°, 2°, and 3° alcohols to the corresponding formates. The reaction employs low catalyst loadings and methyl formate as the formyl transfer reagent. The scope of the reaction is broad with 23 examples reported with good yields (59-96%). The reaction is insensitive to common nitrogen and oxygen protecting groups and can be achieved in the presence of a number of heterocycles.

Original languageEnglish
Pages (from-to)3505-3510
Number of pages6
JournalSynthesis
Volume49
Issue number15
DOIs
Publication statusPublished - 1 Aug 2017

Keywords

  • formate synthesis
  • N-heterocyclic carbene catalysis
  • transformylation

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