Projects per year
Abstract
An N-heterocyclic carbene-catalysed Mukaiyama-Michael addition between several trimethylsilyl (TMS) enol ethers and chalcone derivatives has been discovered. In addition, a related reaction cascade involving dehydrative Mukaiyama aldol followed by a Mukaiyama-Michael addition process has been developed. The later reaction can also be achieved as a three-component coupling reaction. The enantioselective variant of these reactions has been examined with homochiral catalysts. Though these catalysts were active, they fail to achieve enantioinduction.
Original language | English |
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Pages (from-to) | 436-441 |
Number of pages | 6 |
Journal | Australian Journal of Chemistry |
Volume | 70 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2017 |
Projects
- 3 Finished
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New Reaction Cascades Exploiting N-Heterocyclic Carbenes.
Lupton, D. (Primary Chief Investigator (PCI))
Australian Research Council (ARC), Monash University
1/01/15 → 31/12/18
Project: Research
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Extending the frontiers of organocatalysis: New reactions involving nucleophilic carbenes
Lupton, D. (Primary Chief Investigator (PCI))
Australian Research Council (ARC), Monash University
3/01/12 → 31/12/15
Project: Research
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Direct substitution acyl azolium catalysis: new approaches in reaction discovery
Lupton, D. (Primary Chief Investigator (PCI)) & Rovis, T. (Partner Investigator (PI))
Australian Research Council (ARC), Monash University
3/01/12 → 31/12/14
Project: Research