N-acetylcysteine regimens for paracetamol overdose: Time for a change?

Research output: Contribution to journalComment / DebateOtherpeer-review

5 Citations (Scopus)

Abstract

Paracetamol overdose is one of the commonest pharmaceutical poisonings in the world. For nearly four decades, intravenous acetylcysteine regimens have been used to treat most patients successfully and prevent or mitigate hepatotoxicity. However, the rate of occurrence of adverse reactions to acetylcysteine is quite high, and there is a potential for these to be reduced. Recent studies show that distributing the loading-dose of acetylcysteine over the first few hours of treatment may decrease the incidence of adverse reactions. In addition, varying the duration of acetylcysteine administration may potentially benefit certain cohorts of poisoned patients, depending on their risk of developing hepatotoxicity.

Original languageEnglish
Pages (from-to)749-751
Number of pages3
JournalEmergency Medicine Australasia
Volume28
Issue number6
DOIs
Publication statusPublished - Dec 2016

Keywords

  • Acetaminophen
  • Acetylcysteine
  • Antidote
  • Poisoning

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