N-acetyl endorphin in rat spermatogonia and primary spermatocytes

M. C. Cheng; J. A. Clements; A. I. Smith; S. J. Lolait; J. W. Funder

doi:10.1172/JCI111779

N-acetyl endorphin in rat spermatogonia and primary spermatocytes

M. C. Cheng, J. A. Clements, A. I. Smith, S. J. Lolait, J. W. Funder

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Abstract

In previous reports modest levels of β-endorphin have been found by radioimmunoassay in rat testis, and localized by immunofluorescence to the interstitial cells. We have confirmed these previous reports and extended them by showing that the majority of testicular endorphins are acetylated forms, N-acetyl γ-endorphin, N-acetyl α-endorphin, and N-acetyl β-endorphin_1-27. In addition, N-acetylated endorphins are not found in interstitial cells, but are confined to spermatogonia and primary spermatocytes.

Original language	English
Pages (from-to)	832-835
Number of pages	4
Journal	The Journal of Clinical Investigation
Volume	75
Issue number	3
DOIs	https://doi.org/10.1172/JCI111779
Publication status	Published - 1 Jan 1985

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AU - Cheng, M. C.

AU - Clements, J. A.

AU - Smith, A. I.

AU - Lolait, S. J.

AU - Funder, J. W.

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N2 - In previous reports modest levels of β-endorphin have been found by radioimmunoassay in rat testis, and localized by immunofluorescence to the interstitial cells. We have confirmed these previous reports and extended them by showing that the majority of testicular endorphins are acetylated forms, N-acetyl γ-endorphin, N-acetyl α-endorphin, and N-acetyl β-endorphin1-27. In addition, N-acetylated endorphins are not found in interstitial cells, but are confined to spermatogonia and primary spermatocytes.

AB - In previous reports modest levels of β-endorphin have been found by radioimmunoassay in rat testis, and localized by immunofluorescence to the interstitial cells. We have confirmed these previous reports and extended them by showing that the majority of testicular endorphins are acetylated forms, N-acetyl γ-endorphin, N-acetyl α-endorphin, and N-acetyl β-endorphin1-27. In addition, N-acetylated endorphins are not found in interstitial cells, but are confined to spermatogonia and primary spermatocytes.

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JF - The Journal of Clinical Investigation

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N-acetyl endorphin in rat spermatogonia and primary spermatocytes

Abstract

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