TY - JOUR
T1 - Myocardial perfusion abnormalities by intravenous administration of the contrast agent NC100100 in an experimental model of coronary artery thrombosis and reperfusion
AU - Rovai, Daniele
AU - Janerot-Sjöberg, Birgitta
AU - Nagy, András
AU - Marini, Cecilia
AU - Burchielli, Silvia
AU - Castellari, Michele
AU - Morales, Maria Aurora
AU - Trivella, M. Giovanna
AU - Ostensen, Jonny
AU - Distante, Alessandro
AU - L'Abbate, Antonio
PY - 1998/11
Y1 - 1998/11
N2 - The aim of this study was to evaluate a second-generation echo contrast agent (NC100100) for the study of myocardial perfusion. In eight anesthetized open-chest dogs, this agent was injected intravenously under baseline conditions, during acute coronary thrombosis, and after reperfusion, using both fundamental (FI) and harmonic (HI) imaging, both continuous and intermittent imaging, and both ultrasound (US) and integrated backscatter (IBS) imaging. Contrast injections did not modify the hemodynamic parameters. With all imaging modalities, myocardial contrast enhancement (MCE) was higher with intermittent than with continuous imaging (134 vs 82 gray level/pixel using FI, P = 0.02; 62 vs 32 acoustic units using US HI, P = 0.02; and 52 vs 12 dB using IBS, P = 0.05). MCE equally increased using either US or IBS imaging. The accuracy of MCE in detecting perfusion defects during coronary occlusion and myocardial reperfusion after thrombolysis was very good (sensitivity and specificity = 93% and 95% and 89% and 93%, respectively). The extent of myocardial perfusion defects by echo contrast showed a closer correlation with microspheres using HI (r = 0.82) than FI (r = 0.53). Thus, the intravenous administration of NC100100 during intermittent HI allows myocardial perfusion abnormalities to be accurately detected during acute myocardial infarction.
AB - The aim of this study was to evaluate a second-generation echo contrast agent (NC100100) for the study of myocardial perfusion. In eight anesthetized open-chest dogs, this agent was injected intravenously under baseline conditions, during acute coronary thrombosis, and after reperfusion, using both fundamental (FI) and harmonic (HI) imaging, both continuous and intermittent imaging, and both ultrasound (US) and integrated backscatter (IBS) imaging. Contrast injections did not modify the hemodynamic parameters. With all imaging modalities, myocardial contrast enhancement (MCE) was higher with intermittent than with continuous imaging (134 vs 82 gray level/pixel using FI, P = 0.02; 62 vs 32 acoustic units using US HI, P = 0.02; and 52 vs 12 dB using IBS, P = 0.05). MCE equally increased using either US or IBS imaging. The accuracy of MCE in detecting perfusion defects during coronary occlusion and myocardial reperfusion after thrombolysis was very good (sensitivity and specificity = 93% and 95% and 89% and 93%, respectively). The extent of myocardial perfusion defects by echo contrast showed a closer correlation with microspheres using HI (r = 0.82) than FI (r = 0.53). Thus, the intravenous administration of NC100100 during intermittent HI allows myocardial perfusion abnormalities to be accurately detected during acute myocardial infarction.
KW - Contrast echocardiography
KW - Experimental
KW - Harmonic imaging
KW - Myocardial infarction
KW - Myocardial perfusion
UR - http://www.scopus.com/inward/record.url?scp=0031673237&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0031673237
VL - 15
SP - 731
EP - 740
JO - Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques
JF - Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques
SN - 0742-2822
IS - 8 PART I
ER -