TY - JOUR
T1 - MyelomA genetics international consortium
AU - Morgan, Gareth
AU - Johnsen, Hans
AU - Goldschmidt, Hartmut
AU - Palumbo, Antonio
AU - Cavo, Michele
AU - Sonneveld, Pieter
AU - Migel, Jesus
AU - Chim, Char Sang
AU - Browne, Paul
AU - Einsele, Hermann
AU - Waage, Anders
AU - Turesson, Ingemar
AU - Spencer, Andrew
AU - Hajek, Roman
AU - Ludwig, Heinz
AU - Hemminki, Kari
AU - Houlston, Richard
PY - 2012
Y1 - 2012
N2 - While the etiology of multiple myeloma (MM) is largely unknown, evidence for an inherited genetic susceptibility is provided by the two-fold increased risk of the disease seen in first-degree relatives of cases of MM. It is likely that part of this heritable risk is a consequence of the co-inheritance of low-risk genetic variants. The accumulated experience to date in identifying risk variants for other tumors has highlighted difficulties in conducting statistically and methodologically rigorous studies. The MyelomA Genetics International Consortium (MAGIC) includes 16 research groups in Europe, Asia, Australasia, the Middle East and the Americas engaged in studying the genetics of MM. The first goal of MAGIC is to identify and characterize common genetic variants for MM through association-based analyses. Here, we review the rationale for identifying genetic risk variants for MM and our proposed strategy for establishing MAGIC. A? 2012 Informa UK, Ltd.
AB - While the etiology of multiple myeloma (MM) is largely unknown, evidence for an inherited genetic susceptibility is provided by the two-fold increased risk of the disease seen in first-degree relatives of cases of MM. It is likely that part of this heritable risk is a consequence of the co-inheritance of low-risk genetic variants. The accumulated experience to date in identifying risk variants for other tumors has highlighted difficulties in conducting statistically and methodologically rigorous studies. The MyelomA Genetics International Consortium (MAGIC) includes 16 research groups in Europe, Asia, Australasia, the Middle East and the Americas engaged in studying the genetics of MM. The first goal of MAGIC is to identify and characterize common genetic variants for MM through association-based analyses. Here, we review the rationale for identifying genetic risk variants for MM and our proposed strategy for establishing MAGIC. A? 2012 Informa UK, Ltd.
UR - http://informahealthcare.com/doi/pdf/10.3109/10428194.2011.639881
U2 - 10.3109/10428194.2011.639881
DO - 10.3109/10428194.2011.639881
M3 - Article
SN - 1042-8194
VL - 53
SP - 796
EP - 800
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 5
ER -