MycoCAP - Mycobacterium comparative analysis platform

Siew Who Choo, Mia Yang Ang, Avirup Dutta, Shi Yang Tan, Cheuk Chuen Siow, Hamed Heydari, Naresh V.R. Mutha, Wei Yee Wee, Guat Jah Wong

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Abstract

Mycobacterium spp. are renowned for being the causative agent of diseases like leprosy, Buruli ulcer and tuberculosis in human beings. With more and more mycobacterial genomes being sequenced, any knowledge generated from comparative genomic analysis would provide better insights into the biology, evolution, phylogeny and pathogenicity of this genus, thus helping in better management of diseases caused by Mycobacterium spp.With this motivation, we constructed MycoCAP, a new comparative analysis platform dedicated to the important genus Mycobacterium. This platform currently provides information of 2108 genome sequences of at least 55 Mycobacterium spp. A number of intuitive web-based tools have been integrated in MycoCAP particularly for comparative analysis including the PGC tool for comparison between two genomes, PathoProT for comparing the virulence genes among the Mycobacterium strains and the SuperClassification tool for the phylogenic classification of the Mycobacterium strains and a specialized classification system for strains of Mycobacterium abscessus. We hope the broad range of functions and easy-to-use tools provided in MycoCAP makes it an invaluable analysis platform to speed up the research discovery on mycobacteria for researchers. Database URL: http://mycobacterium.um.edu.my.

Original languageEnglish
Article number18227
JournalScientific Reports
Volume5
DOIs
Publication statusPublished - 15 Dec 2015
Externally publishedYes

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