Mycobacterium abscessus complex

Natural history and treatment outcomes at a tertiary adult cystic fibrosis center

Emma Tippett, Samantha Ellis, John Wilson, Tom Kotsimbos, Denis Spelman

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background: Mycobacterium abscessus complex (MAbsC) is a significant management dilemma when taking care of patients with cystic fibrosis (CF). Methods: We undertook a retrospective cohort analysis of all CF patients in whom MAbsC was isolated from 2005 to 2014. The natural history of MAbsC was determined and clinical factors examined in an attempt to predict transient compared to persistent colonization. Results: No correlation was found between recurrent MAbsC isolation and clinical factors such as body mass index, respiratory function, or age. Over two-thirds of our cohort cleared MAbsC colonization with no intervention and no consistent effect on lung function was identified. Four CF patients were initiated on treatment with only one successful outcome. Conclusion: This analysis demonstrates there are no clear predictors of those CF patients who will become persistently colonized with MAbsC and that a significant proportion will spontaneously clear carriage. As treatment success rate is poor, more work is urgently required in improving patient outcomes.

Original languageEnglish
Pages (from-to)109-116
Number of pages8
JournalInternational Journal of Mycobacteriology
Volume7
Issue number2
DOIs
Publication statusPublished - 1 Apr 2018

Keywords

  • Atypical mycobacterium
  • cystic fibrosis
  • Mycobacterium abscessus
  • nontuberculous mycobacterium

Cite this

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abstract = "Background: Mycobacterium abscessus complex (MAbsC) is a significant management dilemma when taking care of patients with cystic fibrosis (CF). Methods: We undertook a retrospective cohort analysis of all CF patients in whom MAbsC was isolated from 2005 to 2014. The natural history of MAbsC was determined and clinical factors examined in an attempt to predict transient compared to persistent colonization. Results: No correlation was found between recurrent MAbsC isolation and clinical factors such as body mass index, respiratory function, or age. Over two-thirds of our cohort cleared MAbsC colonization with no intervention and no consistent effect on lung function was identified. Four CF patients were initiated on treatment with only one successful outcome. Conclusion: This analysis demonstrates there are no clear predictors of those CF patients who will become persistently colonized with MAbsC and that a significant proportion will spontaneously clear carriage. As treatment success rate is poor, more work is urgently required in improving patient outcomes.",
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Mycobacterium abscessus complex : Natural history and treatment outcomes at a tertiary adult cystic fibrosis center. / Tippett, Emma; Ellis, Samantha; Wilson, John; Kotsimbos, Tom; Spelman, Denis.

In: International Journal of Mycobacteriology, Vol. 7, No. 2, 01.04.2018, p. 109-116.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Mycobacterium abscessus complex

T2 - Natural history and treatment outcomes at a tertiary adult cystic fibrosis center

AU - Tippett, Emma

AU - Ellis, Samantha

AU - Wilson, John

AU - Kotsimbos, Tom

AU - Spelman, Denis

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AB - Background: Mycobacterium abscessus complex (MAbsC) is a significant management dilemma when taking care of patients with cystic fibrosis (CF). Methods: We undertook a retrospective cohort analysis of all CF patients in whom MAbsC was isolated from 2005 to 2014. The natural history of MAbsC was determined and clinical factors examined in an attempt to predict transient compared to persistent colonization. Results: No correlation was found between recurrent MAbsC isolation and clinical factors such as body mass index, respiratory function, or age. Over two-thirds of our cohort cleared MAbsC colonization with no intervention and no consistent effect on lung function was identified. Four CF patients were initiated on treatment with only one successful outcome. Conclusion: This analysis demonstrates there are no clear predictors of those CF patients who will become persistently colonized with MAbsC and that a significant proportion will spontaneously clear carriage. As treatment success rate is poor, more work is urgently required in improving patient outcomes.

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