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Mutations in the N-terminal actin-binding domain of filamin C cause a distal myopathy

  • Rachael Duff
  • , Valerie Tay
  • , Peter Hackman
  • , Gianina Ravenscroft
  • , Catriona Ann McLean
  • , Paul Kennedy
  • , Alina Steinbach
  • , Wiebke Schoffler
  • , Peter van der Ven
  • , Dieter Furst
  • , Jaeguen Song
  • , Kristina Djinovic-Carugo
  • , Sini Penttila
  • , Olayinka Raheem
  • , Katrina Reardon
  • , Alessandro Malandrini
  • , Simona Gambelli
  • , Marcello Villanova
  • , Kristen Nowak
  • , David Williams
  • John Landers, Robert Brown, Jr., Bjarne Udd, Nigel Laing

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Linkage analysis of the dominant distal myopathy we previously identified in a large Australian family demonstrated one significant linkage region located on chromosome 7 and encompassing 18.6 Mbp and 151 genes. The strongest candidate gene was FLNC because filamin C, the encoded protein, is muscle-specific and associated with myofibrillar myopathy
Original languageEnglish
Pages (from-to)729 - 740
Number of pages12
JournalAmerican Journal of Human Genetics
Volume88
Issue number6
DOIs
Publication statusPublished - 2011

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