TY - JOUR
T1 - Mutant mouse cerebellum does not provide specific signals for the selective migration and development of transplanted Purkinje cells
AU - Rosenfeld, Jeffrey V.
AU - Richards, Linda J.
AU - Bartlett, Perry F.
PY - 1993/5/28
Y1 - 1993/5/28
N2 - Embryonic cerebellum transplanted to adult Purkinje cell degenerate mice was assessed for integration and Purkinje cell migration by using the antigenic markers Thy-1 and Leu-4. It was found that the grafted cells migrated into the host's molecular layer, but there was no evidence for specific migration of Purkinje cells. Furthermore, grafted cells were found to form normal cerebellar cyto-architecture only with other grafted cells and not with the host's cells.
AB - Embryonic cerebellum transplanted to adult Purkinje cell degenerate mice was assessed for integration and Purkinje cell migration by using the antigenic markers Thy-1 and Leu-4. It was found that the grafted cells migrated into the host's molecular layer, but there was no evidence for specific migration of Purkinje cells. Furthermore, grafted cells were found to form normal cerebellar cyto-architecture only with other grafted cells and not with the host's cells.
KW - Cerebellum replacement
KW - Neural integration
KW - Neural transplantation
KW - Purkinje cell degenerate mouse
KW - Thy-1
UR - http://www.scopus.com/inward/record.url?scp=0027299708&partnerID=8YFLogxK
U2 - 10.1016/0304-3940(93)90664-7
DO - 10.1016/0304-3940(93)90664-7
M3 - Article
C2 - 8361659
AN - SCOPUS:0027299708
SN - 0304-3940
VL - 155
SP - 19
EP - 23
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1
ER -