Mutant mouse cerebellum does not provide specific signals for the selective migration and development of transplanted Purkinje cells

Jeffrey V. Rosenfeld, Linda J. Richards, Perry F. Bartlett

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Abstract

Embryonic cerebellum transplanted to adult Purkinje cell degenerate mice was assessed for integration and Purkinje cell migration by using the antigenic markers Thy-1 and Leu-4. It was found that the grafted cells migrated into the host's molecular layer, but there was no evidence for specific migration of Purkinje cells. Furthermore, grafted cells were found to form normal cerebellar cyto-architecture only with other grafted cells and not with the host's cells.

Original languageEnglish
Pages (from-to)19-23
Number of pages5
JournalNeuroscience Letters
Volume155
Issue number1
DOIs
Publication statusPublished - 28 May 1993
Externally publishedYes

Keywords

  • Cerebellum replacement
  • Neural integration
  • Neural transplantation
  • Purkinje cell degenerate mouse
  • Thy-1

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