Musculoskeletal and endocrine health in adults with cerebral palsy: New opportunities for intervention

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Abstract

Context: Cerebral palsy (CP) increases fracture risk through diminished ambulation, nutritional deficiencies, and anticonvulsant medication use. Studies examining bone mineral density (BMD) in adults with CP are limited. Objective: To examine the relationship between body composition, BMD, and fractures in adults with CP. The effect of functional, nutritional, and endocrine factors onBMDand body composition is also explored. Design: Retrospective cross-sectional study. Setting and Participants: Forty-five adults with CP (mean age, 28.3 ± 11.0 years) who had dualenergy X-ray absorptiometry imaging at a single tertiary hospital between 2005 and 2015. Results: Seventeen (38%) had a past history of fragility fracture; 43% had a Z-score of ±-2.0 at the lumbar spine (LS) and 41% at the femoral neck (FN). In nonambulatory patients, every one unit decrease in FN Z-score increased the risk of fracture 3.2-fold (95% confidence interval, 1.07-9.70; P 2 <0.550;-

Original languageEnglish
Pages (from-to)1190-1197
Number of pages8
JournalThe Journal of Clinical Endocrinology and Metabolism
Volume101
Issue number3
DOIs
Publication statusPublished - 1 Mar 2016

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