Musculoskeletal and endocrine health in adults with cerebral palsy: New opportunities for intervention

A. Trinh; P. Wong; M. C. Fahey; J. Brown; A. Churchyard; B. J. Strauss; P. R. Ebeling; P. J. Fuller; F. Milat

doi:10.1210/jc.2015-3888

Musculoskeletal and endocrine health in adults with cerebral palsy: New opportunities for intervention

A. Trinh, P. Wong, M. C. Fahey, J. Brown, A. Churchyard, B. J. Strauss, P. R. Ebeling, P. J. Fuller, F. Milat

Research output: Contribution to journal › Article › Research › peer-review

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Abstract

Context: Cerebral palsy (CP) increases fracture risk through diminished ambulation, nutritional deficiencies, and anticonvulsant medication use. Studies examining bone mineral density (BMD) in adults with CP are limited. Objective: To examine the relationship between body composition, BMD, and fractures in adults with CP. The effect of functional, nutritional, and endocrine factors onBMDand body composition is also explored. Design: Retrospective cross-sectional study. Setting and Participants: Forty-five adults with CP (mean age, 28.3 ± 11.0 years) who had dualenergy X-ray absorptiometry imaging at a single tertiary hospital between 2005 and 2015. Results: Seventeen (38%) had a past history of fragility fracture; 43% had a Z-score of ±-2.0 at the lumbar spine (LS) and 41% at the femoral neck (FN). In nonambulatory patients, every one unit decrease in FN Z-score increased the risk of fracture 3.2-fold (95% confidence interval, 1.07-9.70; P 2 <0.550;-

Original language	English
Pages (from-to)	1190-1197
Number of pages	8
Journal	The Journal of Clinical Endocrinology & Metabolism
Volume	101
Issue number	3
DOIs	https://doi.org/10.1210/jc.2015-3888
Publication status	Published - 1 Mar 2016

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title = "Musculoskeletal and endocrine health in adults with cerebral palsy: New opportunities for intervention",

abstract = "Context: Cerebral palsy (CP) increases fracture risk through diminished ambulation, nutritional deficiencies, and anticonvulsant medication use. Studies examining bone mineral density (BMD) in adults with CP are limited. Objective: To examine the relationship between body composition, BMD, and fractures in adults with CP. The effect of functional, nutritional, and endocrine factors onBMDand body composition is also explored. Design: Retrospective cross-sectional study. Setting and Participants: Forty-five adults with CP (mean age, 28.3 ± 11.0 years) who had dualenergy X-ray absorptiometry imaging at a single tertiary hospital between 2005 and 2015. Results: Seventeen (38%) had a past history of fragility fracture; 43% had a Z-score of ±-2.0 at the lumbar spine (LS) and 41% at the femoral neck (FN). In nonambulatory patients, every one unit decrease in FN Z-score increased the risk of fracture 3.2-fold (95% confidence interval, 1.07-9.70; P 2 <0.550;-",

author = "A. Trinh and P. Wong and Fahey, {M. C.} and J. Brown and A. Churchyard and Strauss, {B. J.} and Ebeling, {P. R.} and Fuller, {P. J.} and F. Milat",

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doi = "10.1210/jc.2015-3888",

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T2 - New opportunities for intervention

AU - Trinh, A.

AU - Wong, P.

AU - Fahey, M. C.

AU - Brown, J.

AU - Churchyard, A.

AU - Strauss, B. J.

AU - Ebeling, P. R.

AU - Fuller, P. J.

AU - Milat, F.

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Context: Cerebral palsy (CP) increases fracture risk through diminished ambulation, nutritional deficiencies, and anticonvulsant medication use. Studies examining bone mineral density (BMD) in adults with CP are limited. Objective: To examine the relationship between body composition, BMD, and fractures in adults with CP. The effect of functional, nutritional, and endocrine factors onBMDand body composition is also explored. Design: Retrospective cross-sectional study. Setting and Participants: Forty-five adults with CP (mean age, 28.3 ± 11.0 years) who had dualenergy X-ray absorptiometry imaging at a single tertiary hospital between 2005 and 2015. Results: Seventeen (38%) had a past history of fragility fracture; 43% had a Z-score of ±-2.0 at the lumbar spine (LS) and 41% at the femoral neck (FN). In nonambulatory patients, every one unit decrease in FN Z-score increased the risk of fracture 3.2-fold (95% confidence interval, 1.07-9.70; P 2 <0.550;-

AB - Context: Cerebral palsy (CP) increases fracture risk through diminished ambulation, nutritional deficiencies, and anticonvulsant medication use. Studies examining bone mineral density (BMD) in adults with CP are limited. Objective: To examine the relationship between body composition, BMD, and fractures in adults with CP. The effect of functional, nutritional, and endocrine factors onBMDand body composition is also explored. Design: Retrospective cross-sectional study. Setting and Participants: Forty-five adults with CP (mean age, 28.3 ± 11.0 years) who had dualenergy X-ray absorptiometry imaging at a single tertiary hospital between 2005 and 2015. Results: Seventeen (38%) had a past history of fragility fracture; 43% had a Z-score of ±-2.0 at the lumbar spine (LS) and 41% at the femoral neck (FN). In nonambulatory patients, every one unit decrease in FN Z-score increased the risk of fracture 3.2-fold (95% confidence interval, 1.07-9.70; P 2 <0.550;-

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Musculoskeletal and endocrine health in adults with cerebral palsy: New opportunities for intervention

Abstract

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NHMRC Research Fellowship

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Musculoskeletal and endocrine health in adults with cerebral palsy: New opportunities for intervention

Abstract

UN SDGs

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NHMRC Research Fellowship

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