TY - JOUR
T1 - Muscle sympathetic nerve activity peaks in the first trimester in healthy pregnancy
T2 - a longitudinal case study
AU - Hissen, Sarah L.
AU - El Sayed, Khadigeh
AU - Macefield, Vaughan G.
AU - Brown, Rachael
AU - Taylor, Chloe E.
N1 - Funding Information:
The authors assert that this study was conducted with approval of the Human Research Ethics committee, Western Sydney University, and satisfied the declaration of Helsinki.
Publisher Copyright:
© 2017, Springer-Verlag GmbH Germany.
PY - 2017/12/1
Y1 - 2017/12/1
N2 - Objective and methods: Muscle sympathetic nerve activity and baroreflex sensitivity were examined at rest before, during (weeks 6, 11, 17, 22, 25, 33 and 36) and after a normotensive pregnancy. Results: Muscle sympathetic nerve activity is elevated during pregnancy with a large peak in the first trimester (Δ17 bursts/min) and a secondary peak in the third trimester (Δ11 bursts/min). Cardiac baroreflex sensitivity peaked in the first trimester (10 vs. 6 ms/mmHg pre-pregnancy), whereas sympathetic baroreflex sensitivity was greater throughout. Interpretation: The increase in sympathetic outflow early in pregnancy cannot be explained by a reduction in baroreflex sensitivity, while the secondary increase in burst frequency in the third trimester may, in part, be explained by the elevated heart rate.
AB - Objective and methods: Muscle sympathetic nerve activity and baroreflex sensitivity were examined at rest before, during (weeks 6, 11, 17, 22, 25, 33 and 36) and after a normotensive pregnancy. Results: Muscle sympathetic nerve activity is elevated during pregnancy with a large peak in the first trimester (Δ17 bursts/min) and a secondary peak in the third trimester (Δ11 bursts/min). Cardiac baroreflex sensitivity peaked in the first trimester (10 vs. 6 ms/mmHg pre-pregnancy), whereas sympathetic baroreflex sensitivity was greater throughout. Interpretation: The increase in sympathetic outflow early in pregnancy cannot be explained by a reduction in baroreflex sensitivity, while the secondary increase in burst frequency in the third trimester may, in part, be explained by the elevated heart rate.
KW - Baroreflex sensitivity
KW - Blood pressure
KW - Microneurography
KW - Pregnancy
UR - http://www.scopus.com/inward/record.url?scp=85021817688&partnerID=8YFLogxK
U2 - 10.1007/s10286-017-0439-1
DO - 10.1007/s10286-017-0439-1
M3 - Article
C2 - 28674869
AN - SCOPUS:85021817688
SN - 0959-9851
VL - 27
SP - 401
EP - 406
JO - Clinical Autonomic Research
JF - Clinical Autonomic Research
IS - 6
ER -