Muscle sympathetic nerve activity is associated with elements of the plasma lipidomic profile in young asian adults

Nina Eikelis, Elisabeth A. Lambert, Sarah Phillips, Carolina Ika Sari, Piyushkumar A Mundra, Jacquelyn M Weir, Kevin Huynh, Mariee Teresa Grima, Nora E. Straznicky, John B. Dixon, Markus P. Schlaich, Peter J. Meikle, Gavin W. Lambert

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Abstract

Background: Asian subjects are at increased cardio-metabolic risk at comparatively lower body mass index (BMI) compared with white subjects. Sympathetic nervous system activation and dyslipidemia, both characteristics of increased adiposity, appear to be related. We therefore analyzed the association of muscle sympathetic nerve activity (MSNA) with the plasma lipidomic profile in young adult Asian and white subjects. Methods: Blood samples were collected from 101 participants of either Asian or white background (age, 18 to 30 years; BMI, 28.1 6 5.9 kg/m2). Lipids were extracted from plasma and analyzed using electrospray ionization-tandem mass spectrometry. MSNA was quantified using microneurography. The association of MSNA and obesity with lipid species was examined using linear regression analysis. Results: The plasma concentrations of total dihydroceramide, ceramide, GM3 ganglioside, lysoalkylphosphatidylcholine, alkenylphosphatidylethanolamine, and lysophosphatidylinositol were elevated in the Asian subjects relative to the white subjects. After adjustment for confounders, diacylglycerols and triacylglycerols, cholesterol esters, phosphatidylinositols, phosphatidylethanolamines, and phosphatidylglycerols bore significant associations with MSNA but only in the Asian subjects. These associations remained significant after further adjustment for the participants' degree of insulin resistance and appeared not to be related to differences in diet macronutrient content between groups. Conclusions: The lipidomic profile differs between Asian and white subjects. There exists a strong relationship between certain lipid species and MSNA. The association is stronger in Asian subjects, despite their lower BMI. This study demonstrates an association between circulating lipids and central sympathetic outflow. Whether the stronger association between the lipid profile and sympathetic activation underpins the apparent greater risk posed by increased adiposity in Asian individuals merits further attention.

Original languageEnglish
Pages (from-to)2059-2068
Number of pages10
JournalJournal of Clinical Endocrinology and Metabolism
Volume102
Issue number6
DOIs
Publication statusPublished - 1 Jun 2017

Cite this

Eikelis, N., Lambert, E. A., Phillips, S., Sari, C. I., Mundra, P. A., Weir, J. M., ... Lambert, G. W. (2017). Muscle sympathetic nerve activity is associated with elements of the plasma lipidomic profile in young asian adults. Journal of Clinical Endocrinology and Metabolism, 102(6), 2059-2068. https://doi.org/10.1210/jc.2016-3738
Eikelis, Nina ; Lambert, Elisabeth A. ; Phillips, Sarah ; Sari, Carolina Ika ; Mundra, Piyushkumar A ; Weir, Jacquelyn M ; Huynh, Kevin ; Grima, Mariee Teresa ; Straznicky, Nora E. ; Dixon, John B. ; Schlaich, Markus P. ; Meikle, Peter J. ; Lambert, Gavin W. / Muscle sympathetic nerve activity is associated with elements of the plasma lipidomic profile in young asian adults. In: Journal of Clinical Endocrinology and Metabolism. 2017 ; Vol. 102, No. 6. pp. 2059-2068.
@article{23548a4902664d84a36f226119f2ec79,
title = "Muscle sympathetic nerve activity is associated with elements of the plasma lipidomic profile in young asian adults",
abstract = "Background: Asian subjects are at increased cardio-metabolic risk at comparatively lower body mass index (BMI) compared with white subjects. Sympathetic nervous system activation and dyslipidemia, both characteristics of increased adiposity, appear to be related. We therefore analyzed the association of muscle sympathetic nerve activity (MSNA) with the plasma lipidomic profile in young adult Asian and white subjects. Methods: Blood samples were collected from 101 participants of either Asian or white background (age, 18 to 30 years; BMI, 28.1 6 5.9 kg/m2). Lipids were extracted from plasma and analyzed using electrospray ionization-tandem mass spectrometry. MSNA was quantified using microneurography. The association of MSNA and obesity with lipid species was examined using linear regression analysis. Results: The plasma concentrations of total dihydroceramide, ceramide, GM3 ganglioside, lysoalkylphosphatidylcholine, alkenylphosphatidylethanolamine, and lysophosphatidylinositol were elevated in the Asian subjects relative to the white subjects. After adjustment for confounders, diacylglycerols and triacylglycerols, cholesterol esters, phosphatidylinositols, phosphatidylethanolamines, and phosphatidylglycerols bore significant associations with MSNA but only in the Asian subjects. These associations remained significant after further adjustment for the participants' degree of insulin resistance and appeared not to be related to differences in diet macronutrient content between groups. Conclusions: The lipidomic profile differs between Asian and white subjects. There exists a strong relationship between certain lipid species and MSNA. The association is stronger in Asian subjects, despite their lower BMI. This study demonstrates an association between circulating lipids and central sympathetic outflow. Whether the stronger association between the lipid profile and sympathetic activation underpins the apparent greater risk posed by increased adiposity in Asian individuals merits further attention.",
author = "Nina Eikelis and Lambert, {Elisabeth A.} and Sarah Phillips and Sari, {Carolina Ika} and Mundra, {Piyushkumar A} and Weir, {Jacquelyn M} and Kevin Huynh and Grima, {Mariee Teresa} and Straznicky, {Nora E.} and Dixon, {John B.} and Schlaich, {Markus P.} and Meikle, {Peter J.} and Lambert, {Gavin W.}",
year = "2017",
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doi = "10.1210/jc.2016-3738",
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Eikelis, N, Lambert, EA, Phillips, S, Sari, CI, Mundra, PA, Weir, JM, Huynh, K, Grima, MT, Straznicky, NE, Dixon, JB, Schlaich, MP, Meikle, PJ & Lambert, GW 2017, 'Muscle sympathetic nerve activity is associated with elements of the plasma lipidomic profile in young asian adults' Journal of Clinical Endocrinology and Metabolism, vol. 102, no. 6, pp. 2059-2068. https://doi.org/10.1210/jc.2016-3738

Muscle sympathetic nerve activity is associated with elements of the plasma lipidomic profile in young asian adults. / Eikelis, Nina; Lambert, Elisabeth A.; Phillips, Sarah; Sari, Carolina Ika; Mundra, Piyushkumar A; Weir, Jacquelyn M; Huynh, Kevin; Grima, Mariee Teresa; Straznicky, Nora E.; Dixon, John B.; Schlaich, Markus P.; Meikle, Peter J.; Lambert, Gavin W.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 102, No. 6, 01.06.2017, p. 2059-2068.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Muscle sympathetic nerve activity is associated with elements of the plasma lipidomic profile in young asian adults

AU - Eikelis, Nina

AU - Lambert, Elisabeth A.

AU - Phillips, Sarah

AU - Sari, Carolina Ika

AU - Mundra, Piyushkumar A

AU - Weir, Jacquelyn M

AU - Huynh, Kevin

AU - Grima, Mariee Teresa

AU - Straznicky, Nora E.

AU - Dixon, John B.

AU - Schlaich, Markus P.

AU - Meikle, Peter J.

AU - Lambert, Gavin W.

PY - 2017/6/1

Y1 - 2017/6/1

N2 - Background: Asian subjects are at increased cardio-metabolic risk at comparatively lower body mass index (BMI) compared with white subjects. Sympathetic nervous system activation and dyslipidemia, both characteristics of increased adiposity, appear to be related. We therefore analyzed the association of muscle sympathetic nerve activity (MSNA) with the plasma lipidomic profile in young adult Asian and white subjects. Methods: Blood samples were collected from 101 participants of either Asian or white background (age, 18 to 30 years; BMI, 28.1 6 5.9 kg/m2). Lipids were extracted from plasma and analyzed using electrospray ionization-tandem mass spectrometry. MSNA was quantified using microneurography. The association of MSNA and obesity with lipid species was examined using linear regression analysis. Results: The plasma concentrations of total dihydroceramide, ceramide, GM3 ganglioside, lysoalkylphosphatidylcholine, alkenylphosphatidylethanolamine, and lysophosphatidylinositol were elevated in the Asian subjects relative to the white subjects. After adjustment for confounders, diacylglycerols and triacylglycerols, cholesterol esters, phosphatidylinositols, phosphatidylethanolamines, and phosphatidylglycerols bore significant associations with MSNA but only in the Asian subjects. These associations remained significant after further adjustment for the participants' degree of insulin resistance and appeared not to be related to differences in diet macronutrient content between groups. Conclusions: The lipidomic profile differs between Asian and white subjects. There exists a strong relationship between certain lipid species and MSNA. The association is stronger in Asian subjects, despite their lower BMI. This study demonstrates an association between circulating lipids and central sympathetic outflow. Whether the stronger association between the lipid profile and sympathetic activation underpins the apparent greater risk posed by increased adiposity in Asian individuals merits further attention.

AB - Background: Asian subjects are at increased cardio-metabolic risk at comparatively lower body mass index (BMI) compared with white subjects. Sympathetic nervous system activation and dyslipidemia, both characteristics of increased adiposity, appear to be related. We therefore analyzed the association of muscle sympathetic nerve activity (MSNA) with the plasma lipidomic profile in young adult Asian and white subjects. Methods: Blood samples were collected from 101 participants of either Asian or white background (age, 18 to 30 years; BMI, 28.1 6 5.9 kg/m2). Lipids were extracted from plasma and analyzed using electrospray ionization-tandem mass spectrometry. MSNA was quantified using microneurography. The association of MSNA and obesity with lipid species was examined using linear regression analysis. Results: The plasma concentrations of total dihydroceramide, ceramide, GM3 ganglioside, lysoalkylphosphatidylcholine, alkenylphosphatidylethanolamine, and lysophosphatidylinositol were elevated in the Asian subjects relative to the white subjects. After adjustment for confounders, diacylglycerols and triacylglycerols, cholesterol esters, phosphatidylinositols, phosphatidylethanolamines, and phosphatidylglycerols bore significant associations with MSNA but only in the Asian subjects. These associations remained significant after further adjustment for the participants' degree of insulin resistance and appeared not to be related to differences in diet macronutrient content between groups. Conclusions: The lipidomic profile differs between Asian and white subjects. There exists a strong relationship between certain lipid species and MSNA. The association is stronger in Asian subjects, despite their lower BMI. This study demonstrates an association between circulating lipids and central sympathetic outflow. Whether the stronger association between the lipid profile and sympathetic activation underpins the apparent greater risk posed by increased adiposity in Asian individuals merits further attention.

UR - http://www.scopus.com/inward/record.url?scp=85020378174&partnerID=8YFLogxK

U2 - 10.1210/jc.2016-3738

DO - 10.1210/jc.2016-3738

M3 - Article

VL - 102

SP - 2059

EP - 2068

JO - Journal of Clinical Endocrinology and Metablism

JF - Journal of Clinical Endocrinology and Metablism

SN - 0021-972X

IS - 6

ER -