Muscle stem cells

Frederic Relaix, Christophe Marcelle

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Despite being mainly composed of highly differentiated contractile fibers, the adult skeletal muscle possesses the remarkable ability to regenerate, following injury. The cells that are responsible for this capacity are the satellite cells, a small population of adult stem cells positioned under the basal lamina of muscle fibers and that can give rise to both differentiated myogenic cells while maintaining a stem cell pool by a self-renewal mechanism. We will discuss here recent publications on the developmental origin of muscle stem cells, on the signaling pathways that affect their proliferation and differentiation, with reference to works on skeletal muscle formation in the embryo as well as the adult, using the mouse and chick as reference models.
Original languageEnglish
Pages (from-to)748 - 753
Number of pages6
JournalCurrent Opinion in Cell Biology
Volume21
Issue number6
Publication statusPublished - 2009

Cite this

Relaix, Frederic ; Marcelle, Christophe. / Muscle stem cells. In: Current Opinion in Cell Biology. 2009 ; Vol. 21, No. 6. pp. 748 - 753.
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Relaix, F & Marcelle, C 2009, 'Muscle stem cells' Current Opinion in Cell Biology, vol. 21, no. 6, pp. 748 - 753.

Muscle stem cells. / Relaix, Frederic; Marcelle, Christophe.

In: Current Opinion in Cell Biology, Vol. 21, No. 6, 2009, p. 748 - 753.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Muscle stem cells

AU - Relaix, Frederic

AU - Marcelle, Christophe

PY - 2009

Y1 - 2009

N2 - Despite being mainly composed of highly differentiated contractile fibers, the adult skeletal muscle possesses the remarkable ability to regenerate, following injury. The cells that are responsible for this capacity are the satellite cells, a small population of adult stem cells positioned under the basal lamina of muscle fibers and that can give rise to both differentiated myogenic cells while maintaining a stem cell pool by a self-renewal mechanism. We will discuss here recent publications on the developmental origin of muscle stem cells, on the signaling pathways that affect their proliferation and differentiation, with reference to works on skeletal muscle formation in the embryo as well as the adult, using the mouse and chick as reference models.

AB - Despite being mainly composed of highly differentiated contractile fibers, the adult skeletal muscle possesses the remarkable ability to regenerate, following injury. The cells that are responsible for this capacity are the satellite cells, a small population of adult stem cells positioned under the basal lamina of muscle fibers and that can give rise to both differentiated myogenic cells while maintaining a stem cell pool by a self-renewal mechanism. We will discuss here recent publications on the developmental origin of muscle stem cells, on the signaling pathways that affect their proliferation and differentiation, with reference to works on skeletal muscle formation in the embryo as well as the adult, using the mouse and chick as reference models.

M3 - Article

VL - 21

SP - 748

EP - 753

JO - Current Opinion in Cell Biology

JF - Current Opinion in Cell Biology

SN - 0955-0674

IS - 6

ER -