Muscle carnosine is associated with cardiometabolic risk factors in humans

Barbora de Courten, Timea Kurdiova, Maximilian Pangratius J De Courten, Vitazoslav Belan, Inge Everaert, Marek Vician, Helena Jane Teede, Daniela Gasperikova, Giancarlo Aldini, Wim Derave, Jozef Ukropec, Barbara Ukropcova

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background Carnosine is a naturally present dipeptide abundant in skeletal muscle and an over-the counter food additive. Animal data suggest a role of carnosine supplementation in the prevention and treatment of obesity, insulin resistance, type 2 diabetes and cardiovascular disease but only limited human data exists. Methods and Results Samples of vastus lateralis muscle were obtained by needle biopsy. We measured muscle carnosine levels (high-performance liquid chromatography), body fat (bioimpedance), abdominal subcutaneous and visceral adiposity (magnetic resonance imaging), insulin sensitivity (euglycaemic hyperinsulinemic clamp), resting energy expenditure (REE, indirect calorimetry), free-living ambulatory physical activity (accelerometers) and lipid profile in 36 sedentary non-vegetarian middle aged men (45?7 years) with varying degrees of adiposity and glucose tolerance. Muscle carnosine content was positively related to body fat (r = 0.35, p = 0.04) and subcutaneous (r = 0.38, p = 0.02) but not visceral fat (r = 0.17, p = 0.33). Muscle carnosine content was inversely associated with insulin sensitivity (r = -0.44, p = 0.008), REE (r = -0.58, p
Original languageEnglish
Pages (from-to)1 - 12
Number of pages12
JournalPLoS ONE
Volume10
Issue number10 (Art. No: e13870)
DOIs
Publication statusPublished - 2015

Cite this

de Courten, B., Kurdiova, T., De Courten, M. P. J., Belan, V., Everaert, I., Vician, M., ... Ukropcova, B. (2015). Muscle carnosine is associated with cardiometabolic risk factors in humans. PLoS ONE, 10(10 (Art. No: e13870)), 1 - 12. https://doi.org/10.1371/journal.pone.0138707
de Courten, Barbora ; Kurdiova, Timea ; De Courten, Maximilian Pangratius J ; Belan, Vitazoslav ; Everaert, Inge ; Vician, Marek ; Teede, Helena Jane ; Gasperikova, Daniela ; Aldini, Giancarlo ; Derave, Wim ; Ukropec, Jozef ; Ukropcova, Barbara. / Muscle carnosine is associated with cardiometabolic risk factors in humans. In: PLoS ONE. 2015 ; Vol. 10, No. 10 (Art. No: e13870). pp. 1 - 12.
@article{187d4ba2c1fd49a6888293f5f94798c0,
title = "Muscle carnosine is associated with cardiometabolic risk factors in humans",
abstract = "Background Carnosine is a naturally present dipeptide abundant in skeletal muscle and an over-the counter food additive. Animal data suggest a role of carnosine supplementation in the prevention and treatment of obesity, insulin resistance, type 2 diabetes and cardiovascular disease but only limited human data exists. Methods and Results Samples of vastus lateralis muscle were obtained by needle biopsy. We measured muscle carnosine levels (high-performance liquid chromatography), body fat (bioimpedance), abdominal subcutaneous and visceral adiposity (magnetic resonance imaging), insulin sensitivity (euglycaemic hyperinsulinemic clamp), resting energy expenditure (REE, indirect calorimetry), free-living ambulatory physical activity (accelerometers) and lipid profile in 36 sedentary non-vegetarian middle aged men (45?7 years) with varying degrees of adiposity and glucose tolerance. Muscle carnosine content was positively related to body fat (r = 0.35, p = 0.04) and subcutaneous (r = 0.38, p = 0.02) but not visceral fat (r = 0.17, p = 0.33). Muscle carnosine content was inversely associated with insulin sensitivity (r = -0.44, p = 0.008), REE (r = -0.58, p",
author = "{de Courten}, Barbora and Timea Kurdiova and {De Courten}, {Maximilian Pangratius J} and Vitazoslav Belan and Inge Everaert and Marek Vician and Teede, {Helena Jane} and Daniela Gasperikova and Giancarlo Aldini and Wim Derave and Jozef Ukropec and Barbara Ukropcova",
year = "2015",
doi = "10.1371/journal.pone.0138707",
language = "English",
volume = "10",
pages = "1 -- 12",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "10 (Art. No: e13870)",

}

de Courten, B, Kurdiova, T, De Courten, MPJ, Belan, V, Everaert, I, Vician, M, Teede, HJ, Gasperikova, D, Aldini, G, Derave, W, Ukropec, J & Ukropcova, B 2015, 'Muscle carnosine is associated with cardiometabolic risk factors in humans' PLoS ONE, vol. 10, no. 10 (Art. No: e13870), pp. 1 - 12. https://doi.org/10.1371/journal.pone.0138707

Muscle carnosine is associated with cardiometabolic risk factors in humans. / de Courten, Barbora; Kurdiova, Timea; De Courten, Maximilian Pangratius J; Belan, Vitazoslav; Everaert, Inge; Vician, Marek; Teede, Helena Jane; Gasperikova, Daniela; Aldini, Giancarlo; Derave, Wim; Ukropec, Jozef; Ukropcova, Barbara.

In: PLoS ONE, Vol. 10, No. 10 (Art. No: e13870), 2015, p. 1 - 12.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Muscle carnosine is associated with cardiometabolic risk factors in humans

AU - de Courten, Barbora

AU - Kurdiova, Timea

AU - De Courten, Maximilian Pangratius J

AU - Belan, Vitazoslav

AU - Everaert, Inge

AU - Vician, Marek

AU - Teede, Helena Jane

AU - Gasperikova, Daniela

AU - Aldini, Giancarlo

AU - Derave, Wim

AU - Ukropec, Jozef

AU - Ukropcova, Barbara

PY - 2015

Y1 - 2015

N2 - Background Carnosine is a naturally present dipeptide abundant in skeletal muscle and an over-the counter food additive. Animal data suggest a role of carnosine supplementation in the prevention and treatment of obesity, insulin resistance, type 2 diabetes and cardiovascular disease but only limited human data exists. Methods and Results Samples of vastus lateralis muscle were obtained by needle biopsy. We measured muscle carnosine levels (high-performance liquid chromatography), body fat (bioimpedance), abdominal subcutaneous and visceral adiposity (magnetic resonance imaging), insulin sensitivity (euglycaemic hyperinsulinemic clamp), resting energy expenditure (REE, indirect calorimetry), free-living ambulatory physical activity (accelerometers) and lipid profile in 36 sedentary non-vegetarian middle aged men (45?7 years) with varying degrees of adiposity and glucose tolerance. Muscle carnosine content was positively related to body fat (r = 0.35, p = 0.04) and subcutaneous (r = 0.38, p = 0.02) but not visceral fat (r = 0.17, p = 0.33). Muscle carnosine content was inversely associated with insulin sensitivity (r = -0.44, p = 0.008), REE (r = -0.58, p

AB - Background Carnosine is a naturally present dipeptide abundant in skeletal muscle and an over-the counter food additive. Animal data suggest a role of carnosine supplementation in the prevention and treatment of obesity, insulin resistance, type 2 diabetes and cardiovascular disease but only limited human data exists. Methods and Results Samples of vastus lateralis muscle were obtained by needle biopsy. We measured muscle carnosine levels (high-performance liquid chromatography), body fat (bioimpedance), abdominal subcutaneous and visceral adiposity (magnetic resonance imaging), insulin sensitivity (euglycaemic hyperinsulinemic clamp), resting energy expenditure (REE, indirect calorimetry), free-living ambulatory physical activity (accelerometers) and lipid profile in 36 sedentary non-vegetarian middle aged men (45?7 years) with varying degrees of adiposity and glucose tolerance. Muscle carnosine content was positively related to body fat (r = 0.35, p = 0.04) and subcutaneous (r = 0.38, p = 0.02) but not visceral fat (r = 0.17, p = 0.33). Muscle carnosine content was inversely associated with insulin sensitivity (r = -0.44, p = 0.008), REE (r = -0.58, p

UR - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595442/pdf/pone.0138707.pdf

U2 - 10.1371/journal.pone.0138707

DO - 10.1371/journal.pone.0138707

M3 - Article

VL - 10

SP - 1

EP - 12

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 10 (Art. No: e13870)

ER -