Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 549 - 560 |
| Number of pages | 12 |
| Journal | Nature Reviews Drug Discovery |
| Volume | 13 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2014 |
Cite this
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Muscarinic acetylcholine receptors: Novel opportunities for drug development. / Kruse, Andrew C; Kobilka, Brian; Gautam, Dinesh; Sexton, Patrick M; Christopoulos, Arthur; Wess, Jurgen.
In: Nature Reviews Drug Discovery, Vol. 13, No. 7, 2014, p. 549 - 560.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Muscarinic acetylcholine receptors: Novel opportunities for drug development
AU - Kruse, Andrew C
AU - Kobilka, Brian
AU - Gautam, Dinesh
AU - Sexton, Patrick M
AU - Christopoulos, Arthur
AU - Wess, Jurgen
PY - 2014
Y1 - 2014
N2 - The muscarinic acetylcholine receptors are a subfamily of G protein-coupled receptors that regulate numerous fundamental functions of the central and peripheral nervous system. The past few years have witnessed unprecedented new insights into muscarinic receptor physiology, pharmacology and structure. These advances include the first structural views of muscarinic receptors in both inactive and active conformations, as well as a better understanding of the molecular underpinnings of muscarinic receptor regulation by allosteric modulators. These recent findings should facilitate the development of new muscarinic receptor subtype-selective ligands that could prove to be useful for the treatment of many severe pathophysiological conditions.
AB - The muscarinic acetylcholine receptors are a subfamily of G protein-coupled receptors that regulate numerous fundamental functions of the central and peripheral nervous system. The past few years have witnessed unprecedented new insights into muscarinic receptor physiology, pharmacology and structure. These advances include the first structural views of muscarinic receptors in both inactive and active conformations, as well as a better understanding of the molecular underpinnings of muscarinic receptor regulation by allosteric modulators. These recent findings should facilitate the development of new muscarinic receptor subtype-selective ligands that could prove to be useful for the treatment of many severe pathophysiological conditions.
UR - http://www.nature.com/nrd/journal/v13/n7/pdf/nrd4295.pdf
U2 - 10.1038/nrd4295
DO - 10.1038/nrd4295
M3 - Article
VL - 13
SP - 549
EP - 560
JO - Nature Reviews Drug Discovery
JF - Nature Reviews Drug Discovery
SN - 1474-1776
IS - 7
ER -