Murine models of infectious exacerbations of airway inflammation

Malcolm Ronald Starkey, Andrew Gregory Jarnicki, Ama Tawiah Essilfie, Shaan Lae Gellatly, Richard Yong Kim, Alexandra Cerelina Brown, Paul Stephen Foster, Jay Christopher Horvat, Philip Michael Hansbro

Research output: Contribution to journalReview ArticleResearchpeer-review

53 Citations (Scopus)

Abstract

Airway inflammation underpins the pathogenesis of the major human chronic respiratory diseases. It is now well recognized that respiratory infections with bacteria and viruses are important in the induction, progression and exacerbation of these diseases. There are no effective therapies that prevent or reverse these events. The development and use of mouse models are proving valuable in understanding the role of infection in disease pathogenesis. They have recently been used to show that infections in early life alter immune responses and lung structure to increase asthma severity, and alter immune responses in later life to induce steroid resistance. Infection following smoke exposure or in experimental chronic obstructive pulmonary disease exacerbates inflammation and remodeling, and worsens cystic fibrosis. Further exploration of these models will facilitate the identification of new therapeutic approaches and the testing of new preventions and treatments.

Original languageEnglish
Pages (from-to)337-344
Number of pages8
JournalCurrent Opinion in Pharmacology
Volume13
Issue number3
DOIs
Publication statusPublished - 1 Jun 2013
Externally publishedYes

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