Murine in vitro cellular models to better understand adipogenesis and its potential applications

Muhammad Sufyan Vohra, Bilal Ahmad, Christopher J. Serpell, Ishwar S. Parhar, Eng Hwa Wong

    Research output: Contribution to journalArticleResearchpeer-review

    Abstract

    Adipogenesis has been extensively studied using in vitro models of cellular differentiation, enabling long-term regulation of fat cell metabolism in human adipose tissue (AT) material. Many studies promote the idea that manipulation of this process could potentially reduce the prevalence of obesity and its related diseases. It has now become essential to understand the molecular basis of fat cell development to tackle this pandemic disease, by identifying therapeutic targets and new biomarkers. This review explores murine cell models and their applications for study of the adipogenic differentiation process in vitro. We focus on the benefits and limitations of different cell line models to aid in interpreting data and selecting a good cell line model for successful understanding of adipose biology.

    Original languageEnglish
    Pages (from-to)62-84
    Number of pages23
    JournalDifferentiation
    Volume115
    DOIs
    Publication statusPublished - Sep 2020

    Keywords

    • Adipogenesis
    • Adipose tissue
    • Anti-obesity
    • Cellular models
    • Differentiation

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