Murine in vitro cellular models to better understand adipogenesis and its potential applications

Muhammad Sufyan Vohra; Bilal Ahmad; Christopher J. Serpell; Ishwar S. Parhar; Eng Hwa Wong

doi:10.1016/j.diff.2020.08.003

Murine in vitro cellular models to better understand adipogenesis and its potential applications

Muhammad Sufyan Vohra, Bilal Ahmad, Christopher J. Serpell, Ishwar S. Parhar, Eng Hwa Wong

Malaysia Jeffrey Cheah Sch of Med & HS

Research output: Contribution to journal › Article › Research › peer-review

2 Citations (Scopus)

Abstract

Adipogenesis has been extensively studied using in vitro models of cellular differentiation, enabling long-term regulation of fat cell metabolism in human adipose tissue (AT) material. Many studies promote the idea that manipulation of this process could potentially reduce the prevalence of obesity and its related diseases. It has now become essential to understand the molecular basis of fat cell development to tackle this pandemic disease, by identifying therapeutic targets and new biomarkers. This review explores murine cell models and their applications for study of the adipogenic differentiation process in vitro. We focus on the benefits and limitations of different cell line models to aid in interpreting data and selecting a good cell line model for successful understanding of adipose biology.

Original language	English
Pages (from-to)	62-84
Number of pages	23
Journal	Differentiation
Volume	115
DOIs	https://doi.org/10.1016/j.diff.2020.08.003
Publication status	Published - Sep 2020

Keywords

Adipogenesis
Adipose tissue
Anti-obesity
Cellular models
Differentiation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.diff.2020.08.003

Cite this

@article{00600fbbb5244cbb84a8333da942e7fc,

title = "Murine in vitro cellular models to better understand adipogenesis and its potential applications",

abstract = "Adipogenesis has been extensively studied using in vitro models of cellular differentiation, enabling long-term regulation of fat cell metabolism in human adipose tissue (AT) material. Many studies promote the idea that manipulation of this process could potentially reduce the prevalence of obesity and its related diseases. It has now become essential to understand the molecular basis of fat cell development to tackle this pandemic disease, by identifying therapeutic targets and new biomarkers. This review explores murine cell models and their applications for study of the adipogenic differentiation process in vitro. We focus on the benefits and limitations of different cell line models to aid in interpreting data and selecting a good cell line model for successful understanding of adipose biology.",

keywords = "Adipogenesis, Adipose tissue, Anti-obesity, Cellular models, Differentiation",

author = "Vohra, {Muhammad Sufyan} and Bilal Ahmad and Serpell, {Christopher J.} and Parhar, {Ishwar S.} and Wong, {Eng Hwa}",

note = "Funding Information: This study was financially supported by Taylor's University Flagship Research Grant - Scheme Project No: TUFR/2017/003/05. Funding Information: This study was financially supported by Taylor's University Flagship Research Grant - Scheme Project No: TUFR/2017/003/05 . Publisher Copyright: {\textcopyright} 2020 International Society of Differentiation Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

year = "2020",

month = sep,

doi = "10.1016/j.diff.2020.08.003",

language = "English",

volume = "115",

pages = "62--84",

journal = "Differentiation",

issn = "0301-4681",

publisher = "Elsevier",

}

TY - JOUR

T1 - Murine in vitro cellular models to better understand adipogenesis and its potential applications

AU - Vohra, Muhammad Sufyan

AU - Ahmad, Bilal

AU - Serpell, Christopher J.

AU - Parhar, Ishwar S.

AU - Wong, Eng Hwa

N1 - Funding Information: This study was financially supported by Taylor's University Flagship Research Grant - Scheme Project No: TUFR/2017/003/05. Funding Information: This study was financially supported by Taylor's University Flagship Research Grant - Scheme Project No: TUFR/2017/003/05 . Publisher Copyright: © 2020 International Society of Differentiation Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020/9

Y1 - 2020/9

N2 - Adipogenesis has been extensively studied using in vitro models of cellular differentiation, enabling long-term regulation of fat cell metabolism in human adipose tissue (AT) material. Many studies promote the idea that manipulation of this process could potentially reduce the prevalence of obesity and its related diseases. It has now become essential to understand the molecular basis of fat cell development to tackle this pandemic disease, by identifying therapeutic targets and new biomarkers. This review explores murine cell models and their applications for study of the adipogenic differentiation process in vitro. We focus on the benefits and limitations of different cell line models to aid in interpreting data and selecting a good cell line model for successful understanding of adipose biology.

AB - Adipogenesis has been extensively studied using in vitro models of cellular differentiation, enabling long-term regulation of fat cell metabolism in human adipose tissue (AT) material. Many studies promote the idea that manipulation of this process could potentially reduce the prevalence of obesity and its related diseases. It has now become essential to understand the molecular basis of fat cell development to tackle this pandemic disease, by identifying therapeutic targets and new biomarkers. This review explores murine cell models and their applications for study of the adipogenic differentiation process in vitro. We focus on the benefits and limitations of different cell line models to aid in interpreting data and selecting a good cell line model for successful understanding of adipose biology.

KW - Adipogenesis

KW - Adipose tissue

KW - Anti-obesity

KW - Cellular models

KW - Differentiation

UR - http://www.scopus.com/inward/record.url?scp=85090140173&partnerID=8YFLogxK

U2 - 10.1016/j.diff.2020.08.003

DO - 10.1016/j.diff.2020.08.003

M3 - Article

C2 - 32891960

AN - SCOPUS:85090140173

VL - 115

SP - 62

EP - 84

JO - Differentiation

JF - Differentiation

SN - 0301-4681

ER -

Murine in vitro cellular models to better understand adipogenesis and its potential applications

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Cite this