Mumps vaccine associated orchitis: Evidence supporting a potential immune-mediated mechanism

Vanessa Clifford; Jane Wadsley; Bernard Jenner; James Buttery

doi:10.1016/j.vaccine.2010.01.007

Mumps vaccine associated orchitis: Evidence supporting a potential immune-mediated mechanism

Vanessa Clifford
, Jane Wadsley
, Bernard Jenner
, James Buttery

Paediatrics Monash Health

Research output: Contribution to journal › Article › Other

25 Citations (Scopus)

Abstract

We report 3 cases of orchitis following vaccination with mumps-measles-rubella (MMR) vaccine, two with an onset within 3 days following vaccination. Orchitis is a common complication of mumps infection, particularly in post-pubertal males, and is also recognized as a very rare complication of mumps vaccination. These cases, discussed together with a comprehensive review of the existing literature regarding post-vaccine orchitis, highlight uncertainty regarding the pathogenesis of post-vaccine orchitis.

Original language	English
Pages (from-to)	2671 - 2673
Number of pages	3
Journal	Vaccine
Volume	28
Issue number	14
DOIs	https://doi.org/10.1016/j.vaccine.2010.01.007
Publication status	Published - 2010

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SDG 3 Good Health and Well-being

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10.1016/j.vaccine.2010.01.007

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abstract = "We report 3 cases of orchitis following vaccination with mumps-measles-rubella (MMR) vaccine, two with an onset within 3 days following vaccination. Orchitis is a common complication of mumps infection, particularly in post-pubertal males, and is also recognized as a very rare complication of mumps vaccination. These cases, discussed together with a comprehensive review of the existing literature regarding post-vaccine orchitis, highlight uncertainty regarding the pathogenesis of post-vaccine orchitis.",

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AU - Buttery, James

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AB - We report 3 cases of orchitis following vaccination with mumps-measles-rubella (MMR) vaccine, two with an onset within 3 days following vaccination. Orchitis is a common complication of mumps infection, particularly in post-pubertal males, and is also recognized as a very rare complication of mumps vaccination. These cases, discussed together with a comprehensive review of the existing literature regarding post-vaccine orchitis, highlight uncertainty regarding the pathogenesis of post-vaccine orchitis.

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Mumps vaccine associated orchitis: Evidence supporting a potential immune-mediated mechanism

Abstract

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