Multiscale modeling of tumorigenesis induced by mitochondrial incapacitation in cell death

Safee U. Chaudhary, Sung Young Shin, Jae Kyung Won, Kwang Hyun Cho

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4 Citations (Scopus)

Abstract

There is a renewed interest in tumorigenesis provoked by glycolysis and prosurvival autophagy following the mitochondrial permeability transition during cell death. To investigate such mitochondrial dysfunction, we have developed a multiscale model by integrating the dynamic behaviors of essential oncogenic proteins, cells, and their microenvironment. We found that 1) the concentration of cellular ATP (adenosine triphosphate) available during the autophagy-related processes is a critical factor in determining tumorigenesis; 2) mitochondrial aging rate has a significant influence on this tumorigenic effect, 3) specific hypoxic and oxidative stresses work cooperatively for tumorigenesis during cell death. We conclude that the cellular mitochondrial status is critical in triggering tumorigenesis during the cell death process, particularly under harsh microenvironments.

Original languageEnglish
Article number5887398
Pages (from-to)3028-3032
Number of pages5
JournalIEEE Transactions on Biomedical Engineering
Volume58
Issue number10 PART 2
DOIs
Publication statusPublished - 1 Oct 2011

Keywords

  • Autophagy
  • glycolysis
  • mitochondrial apoptosis
  • systems biology
  • tumorigenesis

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