Multiple Tumor Suppressor Genes in Multistep Carcinogenesis

Andrew P. Feinberg, Laura A. Johnson, J. David, Bryan R.G. Williams, Gilles Thomas, C. Richard Boland

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Abstract

One of the most exciting areas of molecular oncology is the convergence of two independent lines of evidence suggesting involvement of multiple tumor suppressor genes in a given type of cancer. First, epidemiology and somatic cell genetics indicate the presence of multiple tumor suppressor genes in each of several malignancies. Second, cancers often lose multiple chromosomal regions during tumor progression. We will use two tumors, colorectal cancer and Wilms tumor, to illustrate the questions that multiple tumor suppressor genes raise.

Original languageEnglish
Pages (from-to)149-152
Number of pages4
JournalTohoku Journal of Experimental Medicine
Volume168
Issue number2
DOIs
Publication statusPublished - 1 Jan 1992
Externally publishedYes

Keywords

  • allelic loss of chromosome
  • DNA methylation
  • multistep carcinogenesis
  • tumor suppressor genes
  • Wilms tumor (WT)

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