Multiple systemic transplantations of human amniotic mesenchymal stem cells exert therapeutic effects in an ALS mouse model

Haitao Sun, Zong-liu Hou, Huaqiang Yang, Ming-yao Meng, Peng Li, Qingjian Zou, Lu-Jun Yang, Yuxin Chen, Huihui Chai, Huilin Zhong, Zara Zhuyun Yang, Jing Zhao, Liangxue Lai, Xiaodan Jiang, Zhi-Cheng Xiao

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12 Citations (Scopus)

Abstract

Abstracts Amyotrophic lateral sclerosis (ALS) is an adult-onset progressive neurodegenerative disease involving degeneration of motor neurons in the central nervous system. Stem cell treatment is a potential therapy for this fatal disorder. The human amniotic membrane (HAM), an extremely rich and easily accessible tissue, has been proposed as an attractive material in cellular therapy and regenerative medicine because of its advantageous characteristics. In the present study, we evaluate the long-term effects of a cellular treatment by intravenous administration of human amniotic mesenchymal stem cells (hAMSCs) derived from HAM into a hSOD1G93A mouse model. The mice received systemic administration of hAMSCs or phosphate-buffered saline (PBS) at the onset, progression and symptomatic stages of the disease. hAMSCs were detected in the spinal cord at the final stage of the disease, in the form of isolates or clusters and were negative for ?-tubulin III and GFAP. Compared with the treatment with PBS, multiple hAMSC transplantations significantly retarded disease progression, extended survival, improved motor function, prevented motor neuron loss and decreased neuroinflammation in mice. These findings demonstrate that hAMSC transplantation is a promising cellular treatment for ALS.
Original languageEnglish
Pages (from-to)571 - 582
Number of pages12
JournalCell and Tissue Research
Volume357
Issue number3
DOIs
Publication statusPublished - 2014

Cite this

Sun, H., Hou, Z., Yang, H., Meng, M., Li, P., Zou, Q., Yang, L-J., Chen, Y., Chai, H., Zhong, H., Yang, Z. Z., Zhao, J., Lai, L., Jiang, X., & Xiao, Z-C. (2014). Multiple systemic transplantations of human amniotic mesenchymal stem cells exert therapeutic effects in an ALS mouse model. Cell and Tissue Research, 357(3), 571 - 582. https://doi.org/10.1007/s00441-014-1903-z