Multiple sclerosis in the Asia Pacific region: A systematic review of a neglected neurological disease

Wing L. Cheong, Devi Mohan, Narelle Warren, Daniel D. Reidpath

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

Background: Multiple sclerosis is thought to be relatively uncommon in the Asia Pacific region with prevalence estimated between 0 and 20 per 100,000. There is reason to doubt these estimates due to the lack of data from many countries and the growing evidence of variability in prevalence across small geographic areas. This study was conducted to systematically review the population prevalence, incidence, mortality and disability progression estimates of MS within the Asia Pacific region. Methods: The systematic review was conducted on articles from 1985 till 31st July 2017 within the PubMed/MEDLINE, EMBASE, SCOPUS, and The Cochrane Library databases. The review included articles that were population-based studies conducted on patients with MS in the Asia Pacific region that reported either incidence, prevalence, mortality, or disease progression. Hospital-based studies and non-research articles were excluded to ensure that only information representative of the population was included for analysis. Data appraisal and extraction was done by independent reviewers. This review was registered with PROSPERO (ID: CRD42017082760). Findings: Of the 2,757 articles found, 16 studies were included. Information on 6 (18.75%) of 32 Asia Pacific countries was found, with data representing 8% of the total population. Prevalence estimates were available for 6 countries while estimates for incidence (3 countries), mortality (4 countries), and disease progression (2 countries) were limited. Interpretation: The lack of epidemiological data available in the Asia Pacific region creates a blind spot in the surveillance of MS which obscures the true burden of MS, causing patients to struggle to receive the resources and funding that they need.

Original languageEnglish
Article number432
Pages (from-to)1-9
Number of pages9
JournalFrontiers in Neurology
Volume9
DOIs
Publication statusPublished - 8 Jun 2018

Keywords

  • Asia Pacific
  • Disability
  • Epidemiology
  • Incidence
  • Mortality
  • Multiple sclerosis
  • Prevalence
  • Registries

Cite this

@article{1a36ec9053164db3851e1e93a99c5299,
title = "Multiple sclerosis in the Asia Pacific region: A systematic review of a neglected neurological disease",
abstract = "Background: Multiple sclerosis is thought to be relatively uncommon in the Asia Pacific region with prevalence estimated between 0 and 20 per 100,000. There is reason to doubt these estimates due to the lack of data from many countries and the growing evidence of variability in prevalence across small geographic areas. This study was conducted to systematically review the population prevalence, incidence, mortality and disability progression estimates of MS within the Asia Pacific region. Methods: The systematic review was conducted on articles from 1985 till 31st July 2017 within the PubMed/MEDLINE, EMBASE, SCOPUS, and The Cochrane Library databases. The review included articles that were population-based studies conducted on patients with MS in the Asia Pacific region that reported either incidence, prevalence, mortality, or disease progression. Hospital-based studies and non-research articles were excluded to ensure that only information representative of the population was included for analysis. Data appraisal and extraction was done by independent reviewers. This review was registered with PROSPERO (ID: CRD42017082760). Findings: Of the 2,757 articles found, 16 studies were included. Information on 6 (18.75{\%}) of 32 Asia Pacific countries was found, with data representing 8{\%} of the total population. Prevalence estimates were available for 6 countries while estimates for incidence (3 countries), mortality (4 countries), and disease progression (2 countries) were limited. Interpretation: The lack of epidemiological data available in the Asia Pacific region creates a blind spot in the surveillance of MS which obscures the true burden of MS, causing patients to struggle to receive the resources and funding that they need.",
keywords = "Asia Pacific, Disability, Epidemiology, Incidence, Mortality, Multiple sclerosis, Prevalence, Registries",
author = "Cheong, {Wing L.} and Devi Mohan and Narelle Warren and Reidpath, {Daniel D.}",
year = "2018",
month = "6",
day = "8",
doi = "10.3389/fneur.2018.00432",
language = "English",
volume = "9",
pages = "1--9",
journal = "Frontiers in Neurology",
issn = "1664-2295",
publisher = "Frontiers Media",

}

Multiple sclerosis in the Asia Pacific region : A systematic review of a neglected neurological disease. / Cheong, Wing L.; Mohan, Devi; Warren, Narelle; Reidpath, Daniel D.

In: Frontiers in Neurology, Vol. 9, 432, 08.06.2018, p. 1-9.

Research output: Contribution to journalReview ArticleResearchpeer-review

TY - JOUR

T1 - Multiple sclerosis in the Asia Pacific region

T2 - A systematic review of a neglected neurological disease

AU - Cheong, Wing L.

AU - Mohan, Devi

AU - Warren, Narelle

AU - Reidpath, Daniel D.

PY - 2018/6/8

Y1 - 2018/6/8

N2 - Background: Multiple sclerosis is thought to be relatively uncommon in the Asia Pacific region with prevalence estimated between 0 and 20 per 100,000. There is reason to doubt these estimates due to the lack of data from many countries and the growing evidence of variability in prevalence across small geographic areas. This study was conducted to systematically review the population prevalence, incidence, mortality and disability progression estimates of MS within the Asia Pacific region. Methods: The systematic review was conducted on articles from 1985 till 31st July 2017 within the PubMed/MEDLINE, EMBASE, SCOPUS, and The Cochrane Library databases. The review included articles that were population-based studies conducted on patients with MS in the Asia Pacific region that reported either incidence, prevalence, mortality, or disease progression. Hospital-based studies and non-research articles were excluded to ensure that only information representative of the population was included for analysis. Data appraisal and extraction was done by independent reviewers. This review was registered with PROSPERO (ID: CRD42017082760). Findings: Of the 2,757 articles found, 16 studies were included. Information on 6 (18.75%) of 32 Asia Pacific countries was found, with data representing 8% of the total population. Prevalence estimates were available for 6 countries while estimates for incidence (3 countries), mortality (4 countries), and disease progression (2 countries) were limited. Interpretation: The lack of epidemiological data available in the Asia Pacific region creates a blind spot in the surveillance of MS which obscures the true burden of MS, causing patients to struggle to receive the resources and funding that they need.

AB - Background: Multiple sclerosis is thought to be relatively uncommon in the Asia Pacific region with prevalence estimated between 0 and 20 per 100,000. There is reason to doubt these estimates due to the lack of data from many countries and the growing evidence of variability in prevalence across small geographic areas. This study was conducted to systematically review the population prevalence, incidence, mortality and disability progression estimates of MS within the Asia Pacific region. Methods: The systematic review was conducted on articles from 1985 till 31st July 2017 within the PubMed/MEDLINE, EMBASE, SCOPUS, and The Cochrane Library databases. The review included articles that were population-based studies conducted on patients with MS in the Asia Pacific region that reported either incidence, prevalence, mortality, or disease progression. Hospital-based studies and non-research articles were excluded to ensure that only information representative of the population was included for analysis. Data appraisal and extraction was done by independent reviewers. This review was registered with PROSPERO (ID: CRD42017082760). Findings: Of the 2,757 articles found, 16 studies were included. Information on 6 (18.75%) of 32 Asia Pacific countries was found, with data representing 8% of the total population. Prevalence estimates were available for 6 countries while estimates for incidence (3 countries), mortality (4 countries), and disease progression (2 countries) were limited. Interpretation: The lack of epidemiological data available in the Asia Pacific region creates a blind spot in the surveillance of MS which obscures the true burden of MS, causing patients to struggle to receive the resources and funding that they need.

KW - Asia Pacific

KW - Disability

KW - Epidemiology

KW - Incidence

KW - Mortality

KW - Multiple sclerosis

KW - Prevalence

KW - Registries

UR - http://www.scopus.com/inward/record.url?scp=85048263115&partnerID=8YFLogxK

U2 - 10.3389/fneur.2018.00432

DO - 10.3389/fneur.2018.00432

M3 - Review Article

VL - 9

SP - 1

EP - 9

JO - Frontiers in Neurology

JF - Frontiers in Neurology

SN - 1664-2295

M1 - 432

ER -